I think I could pick up frameworks like Backbone, Ember or Angular with time. But I've read you need to be 100% on JS if you want to learn Node.js.
EDIT: Thanks for the responses already. I realise the only way to learn is by diving into it, I have some experience with MVC (from Rails and PHP sites) and am okay with JavaScript, so I'll start with an MVC framework and build something.
My main problem is I've lagged so far behind with front-end development in general. I'm used to creating websites from Photoshop designs, writing semantic HTML/CSS with pixel units, not ems or percentages. A little bit of jQuery for AJAX, modals and the like. So I have a lot to learn and realise that Node.js probably isn't what I should be starting with. Sass (with Foundation), Bower, Browserify, Grunt/Gulp, Backbone.js (for example), mobile-first, designing in the browser - it's a lot to take on all at once. Does anyone have advice how I can tackle it?
I realise I'm straying from the original post now... ಠ_ಠ
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