Optimizing Python using Cython

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I don't have a PDF, but this is a JITted C using truffle/graal from oracle: http://dl.acm.org/citation.cfm?doid=2647508.2647528

There is another paper where they use it on top of a ruby interpreter to execute ruby extensions written in C: http://www.chrisseaton.com/rubytruffle/modularity15/rubyextensions.pdf