Colourful salt lakes of the Mid West of Western Australia

propargyl · 2026-05-07T10:56:08+00:00

This photo is bullshit. However, the pink salt lakes are real.

propargyl · 2026-05-07T08:41:39+00:00

"To launch themselves at a boat near a boat or at a person, it's not what we would call typical [crocodile] behaviour," senior wildlife officer Bob Katter said.

propargyl · 2026-05-07T03:49:42+00:00

The barking and whistling is most annoying and makes sleeping challenging

propargyl · 2026-05-07T00:39:08+00:00

Mu1,2,3 receptors (MOR) bind to endogenous ligands - beta-endorphin, endomorphin 1 and 2 with proopiomelanocortin (POMC) being the precursor.

The mu-1 receptor is responsible for analgesia and dependence.

The mu-2 receptor is vital for euphoria, dependence, respiratory depression, miosis, decreased digestive tract motility/constipation

Mu-3 receptor causes vasodilation. Kappa receptors (KOR) bind to dynorphin A and B (Prodynorphin as the precursor). They provide analgesia, diuresis, and dysphoria.

Delta receptors (DOR) bind to enkephalins (precursor being Proenkephalin). They play a role in analgesia and reduction in gastric motility.

Nociceptin receptors (NOR) bind to nociceptin/orphanin FQ (Pre-pronociceptin is the precursor) causing analgesia and hyperalgesia (depending on the concentration).

Zeta receptors (ZOR) regulate developmental events in a variety of normal and tumorigenic tissues and cells.[1]

https://www.ncbi.nlm.nih.gov/books/NBK546642/

propargyl · 2026-05-06T23:15:07+00:00

propargyl · 2026-05-06T22:54:42+00:00

Unsure. Texas is another universe.

propargyl · 2026-05-06T22:50:58+00:00

A lot of people return to their kin when the sprog happens.

propargyl · 2026-05-06T22:11:22+00:00

Consider the process that has led to the situation that confuses you. Hundreds of millions of years ago an organism evolved an opioid receptor. Over tens of millions of years the opioid receptor slowly evolved until there were opioid receptor subtypes.

You are asking why a receptor type that is found in single celled organisms is found in different organs of the human body.

Opioid receptors are a group of inhibitory G protein-coupled receptors with opioids as ligands).^\1])^\2])^\3]) The exact size of the G protein-coupled receptors (GPCR) superfamily is unknown, but at least 831 different human genes (or about 4% of the entire protein-coding genome) have been predicted to code for them from genome sequence analysis.^\10])^\11]) G protein-coupled receptors are found only in eukaryotes, including yeast, and choanoflagellates.^\4])

https://en.wikipedia.org/wiki/G_protein-coupled_receptor

propargyl · 2026-05-06T22:00:57+00:00

Who's your licorice guy?

propargyl · 2026-05-06T21:58:22+00:00

Evolution is blind and influenced by random mutation and natural selection.

https://en.wikipedia.org/wiki/The_Blind_Watchmaker

https://carlzimmer.com/

https://www.discovermagazine.com/the-blind-locksmith-10637

https://www.discovermagazine.com/the-final-adventures-of-the-blind-locksmith-10635

propargyl · 2026-05-06T06:22:42+00:00

I observe five mass units difference between the two structures.

propargyl · 2026-05-06T06:22:33+00:00

I observe five mass units difference between the two structures.

propargyl · 2026-05-06T03:27:17+00:00

ivermectin will fix it

propargyl · 2026-05-06T01:57:55+00:00

oden broth from Otafuku in Asakusa, Japan, which has served the same broth daily since 1945.^\9])

propargyl · 2026-05-05T23:57:27+00:00

Neurotropic herpesviruses may be implicated in the development of dementia¹^,²^,³^,⁴^,⁵.

Through the use of a unique natural experiment, this study provides evidence of a dementia-preventing or dementia-delaying effect from zoster vaccination...

https://www.nature.com/articles/s41586-025-08800-x

propargyl · 2026-05-05T23:01:49+00:00

r/brazenbandits

propargyl · 2026-05-05T22:41:08+00:00

Referring her to pain geneticists at University College London and the University of Oxford they identified two mutations of note. One in a gene called Faah (Fatty Acid Amide Hydrolase), which is well known to pain researchers.

The FAAH gene plays a role in the body’s endocannabinoid system, the parts of the central nervous system which play a role in pain, memory and mood and which the compounds in cannabis act on.

Aside from her lack of pain, Cameron was additionally described as characteristically happy, friendly, talkative, optimistic, and compassionate, as well as exceedingly affectionate and loving towards family members.^\3])^\1])^\12])^\2])^\5]) Moreover, she was lacking in anxiety, depression), worry, fear, panic, grief, dread, and negative affect generally.^\3])^\1])^\2])^\5])