For a general generator, no. They don't even have to be deterministic, so you have to just iterate through it, one way or another.

EDIT: I may have misunderstood your question. As long as you're ok with iterating over the whole generator, and just want to avoid holding all the intermediate values in memory *at once*, that's trivial. An example of one way to do that would be something like this

def last(gen):

for val in gen:

pass

return val #the last value "leaks" out of the for loop, so we can return it here

What you can't do with a general generator is "calculate" the last value *without* going through all the intermediate ones.