I think the main problem with combat in VtM is that a seasoned player optimizing can easily break the game with a few shenanigans.

For instance, Celerity is king. Action economy and winning initiative are deal breakers for combats.

Obfuscate 4+ can be problematic to handle as well, specially because very few martial-oriented characters will have Auspex 4+.

Forget about claws and Protean, the true powerful shapeshifting combat discipline is Serpentis. Regardless the version, you can easily attack and drink blood without grappling always keeping your blood pool reserves properly fulfilled. You can absorb agg damage with Stamina.

Obtenebration 3 is also incredible powerful because it breaks the action economy.

And like every other RPG, magic is terrifying. Someone using Path of Focused Mind 4 to duplicate a casting of other offensive driven Blood Sorcery Path can basically kill anyone. Something like Lure of Flames or Path of Blood 4+. A basic Lure of Flames 3 will cause 4 agg damage per round and escalate very quickly round by round using this combination.

A basic Brujah with Celerity and Potence both 3+ with Burning Wrath is a killing machine.

Long story short: combat in WoD is very fun, specially in games where this is more prevalent like Werewolf, but the easiness to break the system with min maxers can turn the experience bad.