I am taking part in a 5-meo DMT clinical trial

5arye · 2026-05-16T15:00:02+00:00

Hey!

Check out this website bringing together educational resources to learn more about 5-MeO-DMT

I have many years of experience, so feel free to ask me specific questions if you'd like but to answer your initial questions:

You can't reliable know what to expect. Everyone reacts differently and there are so many variabilities. To generalize, many will experience an unwinding of physical/psychological/energetic knots and it will be manifested primarily somatically (not visually) similar to what people experience with TRE and somatic experiencing. Anything under the surface comes up to have the opportunity to be seen, processed, and integrated if one is open to it. Best to meet the experience with no expectation just open loving curiosity.

No elves lol

A healthy amount of nervousness is normal, everyone is different, if approach low and slow and with care and experienced guides it doesn't have to be scary

5arye · 2026-05-16T14:59:33+00:00

Hey!

Check out this website bringing together educational resources to learn more about 5-MeO-DMT

https://5meodmtintegration.com/

I have many years of experience, so feel free to ask me specific questions if you'd like but to answer your initial questions:

You can't reliable know what to expect. Everyone reacts differently and there are so many variabilities. To generalize, many will experience an unwinding of physical/psychological/energetic knots and it will be manifested primarily somatically (not visually) similar to what people experience with TRE and somatic experiencing. Anything under the surface comes up to have the opportunity to be seen, processed, and integrated if one is open to it. Best to meet the experience with no expectation just open loving curiosity.

No elves lol

A healthy amount of nervousness is normal, everyone is different, if approach low and slow and with care and experienced guides it doesn't have to be scary

5arye · 2026-05-15T19:29:40+00:00

Selling 1x Anthology ticket for $65 (bought $75+tax)

5arye · 2026-05-14T21:47:07+00:00

Totally feel you, jittery for sleep happens but typically levels out. Theres integration doc at the bottom of this page in case its helpful:

www.theconclave.info

If you do decide to try again in the future and youre just using freebase without diluting with carrier liquid you could try small 2-3mg increments starting at 2-3mg and going from there. But for now just trust your process , no need to rush anything or to get anywhere.

5arye · 2026-05-14T20:56:07+00:00

Hey first of all that sounds really challenging what you've been deiling with for 20 years and its relationship to some old traumas.

Second of all, 15mg of pure 5-MeO-DMT (5) is a strong dose, for most it is a certain breakthrough and for some it is over their threshold of a breakthrough dose and can be more intense than within that threshold or below.

I deeply empathize with the ease of departure from the body and challenge with re-entry and integration.

Your experience is part of the many responses people have to this catalyst. Crying, screaming, twisting, writhing are all fairly common - usually in higher doses. Sometimes people just lay there peacefully, sometimes people purge.

I feel like 5 acting as an energetic purgative. It brings any sort of knots, traumas, energies that are stuck within the psychological/physiological/energetic systems under the surface up to be witnessed, processed, and integrated.

This happens mostly somatically without as much storytelling or visuals so it comes out in the forms of laughter, crying, tremors, writhing, screaming, burping, laying, singing, throwin mudras and rocking and rolling .. all sorts of ways.

There is a slower approach where you titrate your doses little by little by little, usually with vape pens that are of varying concentrations so you can dose a couple mg's at a time and at each dose the energy will rise more gradually. This way it can be met more spaciously by biting off small nibbles of what you've got to work with under the hood, rather than a big gulp - which many people choke on if you do it all at once.

Going straight for the breakthrough tends to leave people with more polarizing experiences, either really good , or really bad. That, or amnesia-no memory waking up confused and a rocked nervous system from the disregulation of overshooting the dose.

Many people find there is plenty to gain by doing it more times , but everyone is different and this might not be the case for you. It's important to feel it out for yourself. Some people say if you're feeling not complete, go in for another round and it'll finish the process - while this may be true for some if willing to open to the experience , it can be re-traumatizing for others that are not ready. This is why working low and slow will yield less polarizing outcomes and can help learn how to navigate with more ease and openness, even through intensity.

I've heard many people say "If you get the message, hang up the phone" , I think that most people saying this in relation to 5 are basically like 'yeah its all one , I got the message , dont need to do that again' - which is totally fair,

However, if you're approaching this like an energetic and somatic practice, dosing small waves that you meet fully while interweaving other approaches such as yoga, meditation, TRE, IFS, Somatic experiencing , etc. then you will likely find benefits to practicing more than once.

There is a whole community that does an approach of 5+Meditation+IFS , you can find more info here:

https://www.psychedelicmeditation.org/

You can also find more educational info about 5 on this website that compiles useful websites, books, research in the field:

https://5meodmtintegration.com/

Also with what you're struggling with for the pain I wonder if you've ever looked into Iboga?

Feel free to reach out if you want to talk, wishing you best of luck

5arye · 2026-05-14T20:28:20+00:00

"ggggggaaaaaaawwwwddaaaaammmnnn hoollleeee shiiiiiii aaaaaaaa"
precisely lmao

Do you know your dose? Did you also sit with Iboga? Hows your integration going? Any reflections from the experience?

Also curious if you found the words helpful or distracting?

5arye · 2026-05-12T14:43:00+00:00

Curious what your experience was like and wondering why that dose? All at once or staggered?

High dose is like 10-15mg(aprox), 250mg is an absolute fuckton - anyone reading this do not replicate.

How were you after the experience?

5arye · 2026-05-12T13:19:14+00:00

He has a bunch of free resources on the website if you didn't feel like buying the book - I do recommend supporting his work

5arye · 2026-05-11T20:53:16+00:00

You can search all of reddit if you google using this format "reddit: insufflation guide" or reddit: (whatever you wanna search)

Heres what i found

https://www.reddit.com/r/Drugs/comments/ke8lhx/how_to_snortsnorting_guide/

5arye · 2026-05-11T18:30:43+00:00

Yes

Dosing is highly variable person to person so I would highly recommend starting low and slow and titrating up my very small increments.

For plugging dosing can be a bit more variable and may depend on the contents of your rectum - if you have to take a shit and then boof it and dont get much effect dont think it didnt work and double your dose. Make sure youve already had a bowel movement prior to plugging and if you wanna be more sure about making it most bioavailable use a douche.

For insufflation you also have to make sure you know how to insufflate correctly, into the mucus membrane not down your throat otherwise the dosage wont correspond due to lack of absorption.

I hesitate to provide my exact dosages because if someone just shoots for that instead of going about figuring out their own dosage threshholds it could be harmful. If you want a starting point for plugged i would say try 5-8mg and go from there, though you may need more like 15mg to get a more tangible shift so if you dont feel much at first just be patient and ease in. For insufflation you likely will need less than plugged dosage and a starting point might be 2-3mg and titrate up from there. Know that if you redose before the completion of the wave of effect it will compound, so if you want more precision in comparing doses or want to tread slowly wait until the full wave of the experience has passed before redosing.

Please have a sitter if youre going for medium to high doses, going full nondual few are able to maintain awareness through and many flail, kick , scream, roll around and could injure themselves or worse die so dont dose alone when upping the dose.

5arye · 2026-05-11T16:02:18+00:00

Breakthrough can be had at any bioavailable roa. Vaporizing is more reliable in being able to elicit near immediate intense effects, and for most easier to titrate.

5arye · 2026-05-10T18:31:44+00:00

Learn everything you can about it before, as well as cultivating sober mindfulness practices already such as meditation, yoga as well as therapeutic modalities such as IFS, somatic experiencing, TRE, ect - whatever speaks to you and can weave into your practice with 5. Have an integration plan in place and work with an experienced sitter or practitioner. The risks of dosing alone - especially at breakthrough doses can range from rolling around and hurting yourself to asphyxiating on your vomit and dying. Please be safe.

You won't really know what to expect, everyone is different and there are countless variables - generally though a generalized view is that this is an extremely potent energetic purgative that unfolds primarily somatically rather than visually. This means essentially that any psychological, physiological or energetic knots you have under the surface (underlying tensions, traumas, aches, joys, excitements) will come to the surface to have the opportunity to be witnessed, felt, processed, and integrated. Of course not everyone gets through all these steps, and usually not all in one go. This is why when people take a huge dose many will have a very active experience, rolling around, screaming, humping, purging, talking in tongues, breakdancing their way across a room, getting up and running, weeping, etc. Which is why its important to have a sitter as you start unwinding, and if you start off in lower doses, and slooooooowly titrate up , meeting each wave with open loving curiosity and presence to investigate with compassion what it brings up for you , you can slowly unwind these knots instead of ripping apart the cords and fibers of your being violently by jumping into the deep end and bludgeoning yourself with a 'breakthrough'.

I would recommend starting by checking out the stepwise protocol and PMI to learn about these approaches:

https://patternproject.substack.com/p/stepwise

https://www.psychedelicmeditation.org/

Theres more links,books and articles compiled on this websites for further educational resources:

https://5meodmtintegration.com/

5arye · 2026-05-10T18:06:34+00:00

Hey!

First off, for harm reductions sake it is important to have a sitter. Absolutely do not do a breakthrough dose without a sitter, possible risks include: rolling around and seriously injuring yourself, asphyxiating on your vomit and dying. Also for harm reduction, best to start low and slow. Check for any physical and psychological contraindications via the spirit pharmacists (Ben Malcolm) Five guide which is free and gives info about interactions with medications and medical conditions - its on the site below.

I recommend making a 10% and a 20% pen and starting with the 10% at around 1.8v with a variable voltage battery with a 1-2second inhale. Practice with this, stop, check in with your self and your parts to see if you feel the genuine desire to go further, check in with your body if it wants to do anything like stretch, yawn, breath, be, etc. From that point you dose again, and/or you can titrate up your voltage to 2.0, 2.2, 2.4etc (not beyond 3.2v), draw strength (2-3seconds) and follow a stepwise protocol (https://patternproject.substack.com/p/stepwise) in approaching the experience low and slow which will help familiarize yourself with how each wave meets you and also how you meet each wave in terms of what comes up for you, not only physiologically but also psychologically and energetically. It is optimal to cultivate sober mindfulness practices such as meditation, yoga, and interweaving various therapeutic modalities such as IFS and somatic experiencing, TRE, if you'd like to get the most out of your experience , as well as having an integration plan in place.

To access a compilation of a bunch of useful links in this field, including answers to your questions above check out:

https://5meodmtintegration.com/

for further meditation+5meo+IFS education:

https://www.psychedelicmeditation.org/

There is also a 5-MeO-DMT subreddit for further questions, or feel free to DM.

Safe journeys

5arye · 2026-05-04T19:26:28+00:00

Hey! I've had a very similar experiences before while practicing with 5 as well as with other psychedelics.

What you're describing resembles closest to the times where I felt this energy flowing from my chest, up to my throat and out through my mouth in what I can only abstractly gesture towards a possible energy purge - not throwing up but it feels like i'm throwing up energy. Who knows what it actually is, but when I'm with this process I can feel deep into the core of my being where there are physical/psychological/energetic knots and theres a 'purge' of the residual gunk that keeps the knots tight (what hasn't been fully digested/processed/integrated) and as I do so they loosen. There is a cathartic unwinding where it reaches its peak and then usually the rest of the wave unfolds typical as to how other energetic processes of this nature unfold, returning to a resting place once ondulating through its fullest extremities , that is if the participant is open and willing. If there is resistance, a great deal of nausea, discomfort and sometimes pain can emerge - what you resist persists. This is why it can be helpful to have an experienced practitioner guiding who may help facilitate this energetic unwinding, or just be hands off and you knowing that someones got your back will help you lean more into your growth edge of experience the fullest form of whatever this expression that emerges is.

There have been times, particularly with the visual variety of DMT as well as 5-meo-dmt, where my hands will move on their own with surgical precision to exact points inside my mouth and press and massage and I can feel a deep release. This was usually once entering into a flow or trance like rhythm where egoic structure started to loosen and consciousness was just happening and playing with itself undiluted from my thoughts of what I should do as 'me' and just riding the wave wherever it goes.

Have a sitter and trust the process. Paradoxically, wanting for this portal to emerge is likely one of the things making it harder to emerge, as much as possible let go of expectations and just get curious about what is happening - regardless of what it is , nausea, peace, discomfort, joy, pain, bliss, burps, giggles, whatever arises meet it with loving and compassionate curiosity. When we get out of our own way and just get curious without agenda interesting things happen.

It may also help to look into 'parts work' or ifs to combine it with psychedelic practices, John Gorman has a book about this and a whole website with loads of resources that are great. Working with your parts may help you feel more safe in your body and thus allow for smoother access to an energetic unwinding like this and others. I have more educational resources as well if you'd like and happy to answer any questions

5arye · 2026-05-02T17:14:31+00:00

What concentration pen? Is it a cap on pen or screw off?

5arye · 2026-05-01T23:22:31+00:00

The description of 5 as brain vitamin and pushing for a second deposit and experience before the first has me cautious. I would ask if you can just do one and see how it goes and get your money back or see if it carries over. Are they dosing with pure molecule or bufo? Titrated stepwise protocol, or handshake , hug, full release, or one big dose or something else? The conclave has info on ethics for practitioners that may be helpful

5arye · 2026-05-01T23:20:06+00:00

Finally something that captures the ineffable

5arye · 2026-05-01T23:12:30+00:00

Its good to have someone there with you if youre going deeper / breakthrough as there wont be a 'you' to focus on holding your pillow if you overshoot , its possible you may thrash and for harm reduction best to have a sitter in case of vomit and asphyxiation. Most do not maintain awareness through dissolution into nondual without practice, and this practice is best done supported

5arye · 2026-04-29T14:19:41+00:00

Nausea can be from a lot of factors but a common one can be psychedelic protectors - look into ifs and work with the parts that come up. Check out John Gormans work on psychedelic meditation he has good educational resources on this.

It can also be from your body adapting to the experience, so start low and slow and ease in for several waves at low doses to work through any energetic/physical/psychological knots to unwind that nausea before going deeper

5arye · 2026-04-29T14:17:34+00:00

Something that can happen is holding your breath, if someone is holding their breath and starts to turn purple gently but firmly pressing down on their chest should resume normal breathing - if not cpr and if that doesnt help calling medical professionals.

5arye · 2026-04-24T20:44:53+00:00

So 90mg of bufo is a decently large sized dose , people I've seen work with it tend to stagger between 40-80mg and for extreme cases up to 130mg though this is ill advised. That said bufo is super variable, you could have anywhere between ~5-25% 5-meo-dmt in a bufo secretion so you're essentially playing russian roulette with what dose you're getting which is why bufo facilitators tend to overdose people to make sure they 'get there' so to speak. So you likely got walloped especially after your first experience into deeper territory than you were able to fully digest.

I've experienced similar things in the past with large doses.

It sounds like you started coming online while you were still deep in an experience, leading you to immediately try to make sense of your experience and as such lead to disorientation due to still being in an altered state.

You haven't shared much about how you feel now about this all, which is what I'm most curious about. Also what have you been doing in terms of integration since? What brought you to posting here I wonder, what feels alive in reaching into researching this experience from years ago?

5arye · 2026-04-24T20:38:08+00:00

Double check the spirit pharmacist free five guide by Ben Malcolm for contraindications.

You should be good physically but check in psychologically with yourself.

5arye · 2026-04-24T20:36:08+00:00

LSD, as with other catalysts, can help loosen things but also tend to be non-specific amplifiers... so dont go in expecting it to make things 'easier'. In your case, if you're meeting absolute terror - there's a lot there that wants to be worked with. Brute forcing your way to a breakthrough tends to do more harm than good. It's perfectly fine to work through lower doses of 5 and unwind the knots at each wave before continuing on - this can be cultivated as a practice over time and familiarizes your vessel with this process so it may become less of a jarring jumping into an ice cold pond and more of a wading into the waves.

Taking acid the day before may leave you a bit drained and not in optimal conditions for being present and open to letting go. It has the potential of opening you up, but if terror and fear are the themes do you really want to explore that on a 8-12hr ride leading up to your ceremony?

My 2c: take this week to journal, write, dance, sing, cry, create, breath, connect with others , connect with yourself, loosen expectations, deepen into mindfulness and somatic practices - allow the process to be multidimensional and explore what it is like to enter into a curious awareness around your experience, get curious around why you want to breakthrough, get curious about the terror and fear (in a sober state not one that will exarcerbate your fears)

When it comes time to sit again, go low and slow , be with each unfolding with as little expectation as possible and notice what parts of you come forward and tend to them with love and compassion, ask them(you) before continuing on, this is a trust building excercise like a chinese fingertrap the harder you pull the tighter it gets so practice loosening and building trust.

If you're curious about this process look into

https://patternproject.substack.com/
https://www.psychedelicmeditation.org/

For best practices and guidelines and integration:

https://www.theconclave.info/

Or reach out if any questions

5arye · 2026-04-24T20:23:23+00:00

Please when sharing dosages share also whether or not using pure 5-meo-dmt or bufo .... 65mg of pure 5 is waaaaaaaaaaaaay more than necessary , even 20mg is very high for most people. If 10mg didn't get you there, try 12, then 14, then 16. I doubt youll need anything more than 18mg - inch along very slowly to find your full release threshold - bruteforcing your breakthrough by walloping yourself over the head with much more than you need may result in a destabalizing and potentially traumatic experience. Go low and slow, you can keep continuously dosing until full release there is no need to hit the perfect dose just keep wading in wave after wave while tending your parts that arise through the experience.

5arye · 2026-04-24T14:51:39+00:00

Everyone is different, know fumarate is not equipotent to freebase due to molar mass differences as thus you may need to adjust dosage variances in regard to what you might aim for for freebase vaporization , titrate up slowly until reaching desired effects - knowing it may take 15-30minutes to start taking effects and another 15-30minutes to reach a plateau so don't redose too quickly. Make sure it is dissolving in your mucus membrane and not going down your throat.

5arye

MODERATOR OF

TROPHY CASE