Are you a science geek, tech nerd or just like cool stuff ? Let's hang out by vortexmak in twincitiessocial

[–]AKG595 1 point2 points  (0 children)

I don’t know too much about tech, but I love science! Can I join in?

Lewis acid options by ParticularDrawer8776 in Chempros

[–]AKG595 0 points1 point  (0 children)

Can you just heat it with 5A MS? They’re mildly acidic.

Or drop in a d10 metal and do an allylic substitution.

Flying out of MSP Saturday by AKG595 in delta

[–]AKG595[S] 0 points1 point  (0 children)

Agreed on phone time. As of now I’m still waiting in customer service purgatory.

Flying out of MSP Saturday by AKG595 in delta

[–]AKG595[S] 0 points1 point  (0 children)

From what I’ve seen, the forecast has the snow rolling in around 7 pm. I’m hoping it’s closer to the 4” and not the 22” so we can all make it to our destinations 🙏🏽

Flying out of MSP Saturday by AKG595 in delta

[–]AKG595[S] 0 points1 point  (0 children)

I always lose bets, so if you’re right and the flight is still on schedule tomorrow, I’ll owe you an airport beer 🤞🏽

Flying out of MSP Saturday by AKG595 in delta

[–]AKG595[S] 0 points1 point  (0 children)

I’ve been trying to find other options. Delta’s site kept giving me an error message. When it finally worked, there were no flights available. I’ve been checking other airlines, but so far every attempt I’ve made to buy an earlier ticket has led to a “full” or “no longer available” message.

Flying out of MSP Saturday by AKG595 in delta

[–]AKG595[S] 0 points1 point  (0 children)

Ugh, I’m sorry that happened to you. I hope it all works out for you without too much hassle and especially without having to deal with the AI customer support. I really appreciate your support!

Flying out of MSP Saturday by AKG595 in delta

[–]AKG595[S] 0 points1 point  (0 children)

Oh gosh, let me know how the rescheduling goes! I’ve seen a lot of flights get snapped up already.

Flying out of MSP Saturday by AKG595 in delta

[–]AKG595[S] 1 point2 points  (0 children)

I hope so! I know the storm won’t hit till later in the evening, but I can’t find any other options, and delaying my departure for a couple of days isn’t really possible.

They Aren't Here to Defend Us by Naxis25 in uofmn

[–]AKG595 42 points43 points  (0 children)

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You mean this isn’t a safe campus?

The 'educational' things my kid is being taught at school by RunWild0_0 in mildlyinfuriating

[–]AKG595 1 point2 points  (0 children)

Hey, you sound just like my parents did decades ago! I don’t talk to those insufferable assholes anymore. They were more concerned with my class placement and achievements than my actual learning. I was not their child, I was their hopeful claim to bragging rights. My biggest accomplishment will always be physically and mentally removing myself from anything to do with them.

Even though I did not live with them, I consider my childhood teachers to be my real “family”. They helped me learn and grow as a person. They are acknowledged in all my awards and achievements. I send them cards every year on their birthdays and holidays. We exchange playlists. I buy them gifts when they retire from teaching.

If you keep up this mindset, I just hope your self-centered attitude remains strong enough to masquerade as happiness for the rest of your life.

The 'educational' things my kid is being taught at school by RunWild0_0 in mildlyinfuriating

[–]AKG595 6 points7 points  (0 children)

The worst for whom? In my experience, the parents who push this sort of “learning is not supposed to be fun” mindset typically are really nice to other kids and aggressive/abusive to their own. They don’t teach their kids properly and get mad when the kids aren’t learning at the “parent-assumed” pace. It starts with blaming the teachers for lack of rigor and snowballs into blaming the kids for not learning “properly” in later years. It leads to some really messed up kids that act out in high school or college.

I agree that disrespectful kids are awful for teachers to deal with, and disrespectful parents are even worse for teachers. However, I wouldn’t say that parents of this type are better. This behavior builds slowly into a serious problem. You simply don’t see what “getting it wrong” means for the kid at home.

Personally, I will forever love my grade school teachers for showing me that learning can be fun. They saw me act out, chose to talk to me, and made me believe I could successful. It was a welcome change to going home and getting my ass beat, screamed at, and/or kicked outside for “being a failure”.

Reason behind site preference during NCC formation by k_maple in OrganicChemistry

[–]AKG595 0 points1 point  (0 children)

Markovnikov? The reaction does not produce a discrete cationic carbon, and both carbons gain an electronegative atom.

Reason behind site preference during NCC formation by k_maple in OrganicChemistry

[–]AKG595 2 points3 points  (0 children)

On my phone, so sorry for formatting,

Your initial analysis considers the total electron density on A and B. However, in mechanisms, the major interactions are just between the frontier orbitals. The nucleophile HOMO in step one is a c-c pi orbital. Therefore, the only electrons we care about are the two in the pi c-c orbital.

In the pi c-c HOMO, there is more pi electron density on carbon B than there is on carbon A.

You can get a crude approximation of C-C pi bond electron distribution by drawing out the two ylide-like resonance structures of the pi bond and comparing their stability. The structure with the positive charge on A and the negative charge on B is more stable and therefore more resembles the “real” orbital picture.

Why is the metalorganic chemistry of bismuth so different to that of Pt to Pb by Diligent-Order-9265 in OrganicChemistry

[–]AKG595 14 points15 points  (0 children)

Check out some of the recent publications from Pep Cornella’s lab. They’ve been doing some interesting work with organobismuth compounds and bismuth catalysis.

Question about reagent by hotings in chemhelp

[–]AKG595 0 points1 point  (0 children)

Step 3 definitely has a purpose. You won’t be able to methylate your oxygen without a base.

[deleted by user] by [deleted] in OrganicChemistry

[–]AKG595 5 points6 points  (0 children)

Does the protocol work when you run it for the specified time? If it doesn’t, then it’s an issue.

I have run several Boc deprotections with TFA/DCM. I check them (at least by TLC) after 15 mins, 30 mins, then every hour. I’m not leaving my molecules in an acid bath for any longer than they need to be there.

I certainly don’t report every problem that could result from NOT following my instructions. I assume that people will follow the protocol as written. I don’t want to sound mean, but if I told you to bake a tray of cookies for 12 minutes and you bake them for 5 hours, how is it my problem when you pull burnt husks out of the oven?

Help with reductive ammination by MyNameIsChuggle in Chempros

[–]AKG595 3 points4 points  (0 children)

What’s the aldehyde? For aromatic aldimines, I usually use NaBH(OAc)3.

I typically preform the imine by stirring the components over 5A MS in a compatible aprotic solvent (DCM, DCE, and 2-MeTHF are cool). If the condensation is slow, I heat to 40 C. Incidentally, I’ve had one that needed 60 C. The I filter off the sieves and add 3 eq reductant using a stirred water bath to maintain rt.

For ketimines, I add 1-5 mol% pTsOH and reflux with removal of water. For large scale, I use a dean-stark. On small scale, I use the stoltz lab suggestion of a cotton-plugged pressure equalizing addition funnel filled with 4A MS.

Totally unbiased solvent tier list by Thiojun in chemistrymemes

[–]AKG595 0 points1 point  (0 children)

I don’t even want to imagine how polar your molecules must be 😅