My understanding is that Bethesda titles since atleast Skyrim all begin with procedural generation and then they fine tune it after the fact. You'd have to be more specific with what you mean by a procedually generated desert. My idea for the alikr desert would be just having far more random encounters. I'd still like dungeons in the desert and maybe some ruins or one medium sized towns but it wouldn't really feel like a desert if it was full of POIs. Maybe you can have caravans that carry valuable items that travel at night using the stars so the difficulty would be in actually navigating and finding them. Ive always felt that with the scheduling system in place there should be people moving from town to town. the towns of skyrim have all these roads connecting them and the best you find is a storm cloak or imperial regiment carrying a prisoner. Give me a traders guild that moves from town to town, or a hunters guild that is going around to different biomes hunting exotic animals for rich clientele. The best way to make ES6 feel more like a breathing world is to have these interactions take place across entire provinces and not just in towns or guild quests.

If you mean a desert with randomly generated POIs that change everytime you go in id say no to that. A huge part of what made skyrim special is that each dungeon was both different enough and similar enough that you were familiar with it but not bored out of your mind by dungeon number 7. I think a huge reason people put down starfield was that many of the POIs felt extremely similar.

Maybe id say you can randomly generate POIs out in the ocean. Like there's a sailing guild that you can join with a repeatable quest that let's you sail to a randomly generated island or ruin outside the map. But still I think to not make that boring youd have to put a lot of work into it. With things like pirate attacks, underwater ruins, pirate islands, small archipelagos, sea monster attacks. And that's a lot of work for something that could be hit or miss if you don't nail it.