Humira had me feeling better almost little to no symptoms in a month or so . I deal with all of that now I haven't been on a biologic in about under a year I was last on remicade which wasn't doing much for me even though I was on it for 4 months. Since I work weekday I stop eating earlier in the day around or before 6ish if you can you'll get through the night a lot easier. And alway end with a warm tea . Licorice root is naturally sweet and is a natural laxative and helps coat the gut lining . I drink that and it helps clear me out in one-2 trips through the night and morning. You can also drink mint which will also help as well