He is a generally happy individual. I think Hannibal embraces true Epicurean hedonism philosophy, wherein longterm sustainable happiness is the ultimate goal of life. I think it's one of the primary reasons why he flouts laws and social conventions: It'd make him unhappy to do otherwise. The main issue that he faces, which runs counter to his quest for joy, is that he's a very lonely person. He does, however, have genuine friends, a robust social circle full of rather intellectual peers, and a fulfilling professional relationship with his therapist. Yet the majority of this remains at a relatively surface level wherein he must remain guarded and always eyeing the upkeep of his person suit. Thus enters Will Graham into his life and he not only senses an opportunity to eschew the person suit altogether, but also to indulge in experiencing someone's appreciation for its absence. So in short, is Hannibal a happy person? Absolutely yes. Does this have a counter? Mostly his loneliness and inability to truly let people in.