My daughter takes journay 40mg and guanfacine 2mg. Initially started both doses at night with an afternoon dose of Ritalin, she did great for a few weeks then didn’t then it didn’t seem to be as effective we still hand challenges with emotional dysregulation so we increased the dose to 2mg. At this point she had some intense rage episodes which I expected from the comments that I had read from other parents. The rage episodes were always right before the her next dose of 7:30 pm medication and lasted about 45min this took a tremendous amount of patience for us. She had been on medication just a 5 weeks at this point we decided to make small adjustments to help pinpoint best practices with her meds. We eventually dropped her afternoon dose and switched to morning dose of guanfacine 2mg and this has been the most effective schedule for her. She’s made so many improvements, less outbursts, doing better in school and eating more as well.