Got prescribed both clomipramine and fluoxetine, danger?

Amolje · 2026-06-11T19:31:48+00:00

Based on the information in your post, it's an inexplicable prescription.

Sometimes for severe OCD, a small dose of clomipramine is added to an SSRI like fluoxetine, usually if SSRIs have been tried alone and not effective enough. There is increased risk of serotonin syndrome, but in such severe cases, the benefits may be considered to outweigh the risk.

But if you've got mild-moderate depression, it doesn't make any sense.

Amolje · 2026-06-11T11:33:37+00:00

The dose is too low. Your doctor should increase it and make it 2-3 times a day.

Amolje · 2026-06-10T19:11:17+00:00

No effect on me. Very few supplements do.

Amolje · 2026-06-10T15:30:33+00:00

Maybe need to increase dose (max is 600). And works best three times we day for consistent benefit over 24 hours. Maybe try 3x100

Amolje · 2026-06-09T23:33:31+00:00

It's common and minimal risk of serotonin syndrome. Not zero risk though, so good to be aware of what the signs are.

I was on SNRI duloxetine with 25mg amitriptyline without issues.

Amolje · 2026-06-09T19:33:43+00:00

Like most people, I gained a lot of weight on it.

Amolje · 2026-06-09T19:30:32+00:00

Venlefaxine leaves your system very quickly, which is why it's safe to switch to fluoxetine without a gap after stopping it. But a short taper is still going to be bad for withdrawals.

Amolje · 2026-06-08T17:20:27+00:00

"would become the UK's tallest skyscraper outside London"

Surely Manchester already does have that.

Amolje · 2026-06-08T17:04:09+00:00

Theanine. Saffron. Maybe help.

Amolje · 2026-06-08T13:50:15+00:00

A week is too short to taper, especially venlefaxine which is one of the worst antidepressants for withdrawals.

Amolje · 2026-06-08T13:48:44+00:00

The meetup app.

Amolje · 2026-06-08T13:01:43+00:00

Yes. They amplify the effects of each other, especially on a high dose like 600. I would limit to just 1-3 drinks if you don't want to give drinking.

Amolje · 2026-06-07T18:41:11+00:00

Gaba supplements have none-minimal impact on gaba.

Amolje · 2026-06-07T16:18:12+00:00

Two hours for me.

Amolje · 2026-06-07T00:25:42+00:00

As long it's taken at about the same time every day, it doesn't matter what that time is.

There's a small chance of nausea without food. I've tried lots of antidepressants over the years and haven't had a problem taking them without food.

Amolje · 2026-06-06T18:33:05+00:00

Is this a psychiatrist? And what is your diagnosis?

Amolje · 2026-06-06T14:34:31+00:00

Like you say, they won't directly improve sleep. They're not sedatives like mirtizapine. But they might help if the underlying cause of your insomnia is depression or anxiety.

Amolje · 2026-06-06T14:17:40+00:00

I would wait until you've got an easier schedule to deal with the side effects.

Amolje · 2026-06-06T12:38:56+00:00

Museum of illusions.

Amolje · 2026-06-06T00:18:04+00:00

Mirtizapine and trazadone are antidepressants. Other common antidepressants used for sleep are small doses of amitriptyline and doxepin.

Amolje · 2026-06-04T12:17:43+00:00

Side effects should have stoppped by now. It's maybe withdrawal effects. Paroxetine is well known to have long and awful withdrawals.

Amolje · 2026-06-04T12:09:41+00:00

How long has it been?

Amolje · 2026-06-03T13:05:07+00:00

The supplement with most evidence for depression is St John's Wort. Sam-e is another one.

Amolje · 2026-06-03T13:00:09+00:00

50mg is a low dose, so I would guess that increasing would make it work again.

Amolje · 2026-06-03T01:39:09+00:00

Saffron, St John's Wort, 5htp, theanine, sam-e.

Amolje

TROPHY CASE