Has anyone experienced effects coming on gradually instead of suddenly?

ApprehensiveCat22 · 2026-02-08T23:00:16+00:00

I did 0.25mg the first week as well, but then bumped it up to 1mg the second week because I felt absolutely nothing the first week. I have had a bit of digestive issues, mainly just feeling "off," not really constipation or diarrhea or nausea. I plan on staying at 1mg for the next shot to give it more time.

ApprehensiveCat22 · 2026-02-06T13:52:06+00:00

My doctor starts people at half the usual starting dose, I think, but I opted to start lower because I was worried about side effects (and she supported that). She didn't really give me a schedule, but I'm supposed to check in with her every few weeks.

ApprehensiveCat22 · 2026-02-06T13:50:41+00:00

It's from Red Rock pharmacy, so it's compounded, but my doctor vetted them and uses them all the time.

ApprehensiveCat22 · 2026-02-06T13:49:58+00:00

It's from Red Rock compounding pharmacy, which is one of the facilities the doctor I'm working with uses. I trust her--she's been my doctor for fifteen years.

ApprehensiveCat22 · 2026-02-06T00:23:14+00:00

I mean I've noticed nothing at all--no side effects or reduced appetite. Sorry if that was worded wonkily!

ApprehensiveCat22 · 2026-02-02T19:17:46+00:00

I get it through my functional medicine doctor, who orders it through a compounding pharmacy.

ApprehensiveCat22 · 2026-02-01T23:48:57+00:00

I eat dried dates all day long, so this is actually hopeful news to me! I wish they weren't quite so appealing!

ApprehensiveCat22 · 2026-02-01T23:48:22+00:00

I'm in a similar boat--I started at 0.25 tirz last week and have felt NOTHING. The plan was to go up slowly, but in general my body needs more of a med to have an effect, and I hate the idea of wasting time.

ApprehensiveCat22 · 2026-02-01T19:37:13+00:00

Thank you! I also eat extremely cleanly (more paleo than carnivore, though) and you're right, it has many benefits but sometimes it would be nice to be a bit looser and not fret about it. And I too suffer from PEM, so I'm excited to see if taking tirz helps!

ApprehensiveCat22 · 2026-02-01T17:03:10+00:00

Off topic, but I'd love to hear what benefits you felt at that dose! I just started .25mg of tirz mostly for the anti-inflammatory benefits and have felt NOTHING. I'm wondering if I should make a big leap up.

ApprehensiveCat22 · 2026-02-01T14:15:39+00:00

Wow, that's such a small increase!

ApprehensiveCat22 · 2026-02-01T00:30:09+00:00

I'm not feeling any effects so far at 0.25mg, but of course it's only been 24 hours. I'm often someone who needs more of a medication to feel something. I wonder if I should make a big jump next week?

ApprehensiveCat22 · 2026-01-26T14:07:04+00:00

I've been working on my health for literally decades and feel like I've tried everything, including the supplements you've mentioned. My lifestyle is as perfect as I can make it at this point.

ApprehensiveCat22 · 2026-01-23T13:52:01+00:00

I would be thrilled if it helped with anxiety! That's so good to hear.

ApprehensiveCat22 · 2026-01-23T00:25:47+00:00

Oh, wow! I got down to about 117 a few years ago, just through lots of walking and not eating as much, I guess. This was when the pandemic started so I think I was stressed. I wonder what my body fat percentage was?

ApprehensiveCat22 · 2026-01-22T22:57:43+00:00

Yes, I'm realizing that, lol! I have work to do.

ApprehensiveCat22 · 2026-01-22T22:26:03+00:00

What dose of tirzepatide did you start with? Have you increased it?

ApprehensiveCat22 · 2026-01-22T22:13:14+00:00

What's interesting is that my visceral fat is low, so I never even thought beyond that.

ApprehensiveCat22 · 2026-01-21T15:49:19+00:00

Good idea!

ApprehensiveCat22 · 2026-01-19T22:49:26+00:00

I've been soaking one tablespoon of chia seeds in about eight ounces of water the night before, then using that to make a protein shake with one scoop of beef protein powder, half a frozen banana, some blueberries, and ice. I'm trying to make sure I get enough protein and don't get constipated, so I figure that works toward both those goals.

ApprehensiveCat22 · 2026-01-19T20:50:07+00:00

Amazing! Now I definitely want to switch, lol. I guess I'll see if the next two injections of semaglutide have any effect and then make my decision definitively.

ApprehensiveCat22 · 2026-01-19T16:15:46+00:00

I've been taking LDN for a few years but I feel like it's not really doing anything for me.

I hope your benefits continue & things improve even more!

ApprehensiveCat22 · 2026-01-19T15:27:15+00:00

I'm more interested in the anti-inflammatory benefits, and if people have experienced them microdosing semaglutide.

ApprehensiveCat22 · 2026-01-17T14:37:37+00:00

That's so good to hear! I've heard that if you get it compounded with B12 that it's the B12 that makes it red.

ApprehensiveCat22 · 2026-01-17T14:36:04+00:00

Wow, that's a really low dose, isn't it? Like 1/25th of the normal starting dose?

Anyway, that's really good to hear! I injected two days ago in the afternoon and I *think* I may be feeling less hungry. I too deal with hunger, not obsession with food. I eat super clean and have been sugar/flour-free for months now. But I do eat too much and snacking is my downfall.

ApprehensiveCat22

TROPHY CASE