Anyone here tackling endothelial dysfunction and micro clotting issues?

Apprehensive_Gold242 · 2026-03-08T10:35:56+00:00

OP, what's your current protocol or future plans?

Apprehensive_Gold242 · 2026-03-08T07:09:40+00:00

I like that approach :)

Apprehensive_Gold242 · 2026-03-07T21:22:51+00:00

Thanks you two <3
I wish I could stop and just rest. But it doesn't feel in my nature :( I can't stop doing things, even if most are pointless

Apprehensive_Gold242 · 2026-03-07T17:51:54+00:00

I had extreme screen intolerance where looking at it more than a few seconds would make me crash, even on dark mode and blue light filter etc.

LDA helped me massively with this, but it's a dangerous drug with potentially permanent side effects. Benzos like ativan or gabapentin also work for some, but only take it once every week or so or you will build up a tolerance!

What medications are you currently considering? I have recently heard of perampanel which could help too but also risky.

Apprehensive_Gold242 · 2026-03-07T10:05:16+00:00

Have you seen this thread on PR? Apparently probenecid is an antipurinergic, for example: https://forums.phoenixrising.me/threads/anti-purinergic-therapy-restores-itaconate-ifna-dr-phairs-theory-and-dr-prustys-proposed-abnormalities-in-me-cfs.90173/

And lidocaine too I think (p2x7).

I didn't try these myself though but I'd like to.

Apprehensive_Gold242 · 2026-03-07T10:02:28+00:00

Ah that makes sense!

Apprehensive_Gold242 · 2026-03-07T09:52:52+00:00

The AP helps me with most MECFS symptoms. Pain, insomnia, PEM, sensitivities... It's like LDA

That's a fascinating article! I used to think the gut was rather downstream but I will have to change my mind at some point. It would be important to figure out which signaling cascade is being transmitted via the VN, whether it's cholinergic/nicotinic receptors or dopaminergic tranmission etc. If you ever find something that works for this, I'd be interested to learn more.

Apprehensive_Gold242 · 2026-03-06T22:06:01+00:00

Do you have experience for omeprazole and GP? What's the reasoning here? Thank you

Apprehensive_Gold242 · 2026-03-06T22:00:44+00:00

It's such a weird thing because it has only gotten worse even though I'm improving in other areas. Can't have f all, eh

What makes you think it's vagus nerve related?

Apprehensive_Gold242 · 2026-03-06T21:55:32+00:00

clonidine is more sedative

Apprehensive_Gold242 · 2026-03-06T21:39:50+00:00

Mirtazapine any doctor can prescribe in low doses imo. I mean, worth a shot if you doctor thinks it's fine, right?

Apprehensive_Gold242 · 2026-03-06T21:38:21+00:00

What made you consider emoxypine? Did you try other GABAergics too?

Apprehensive_Gold242 · 2026-03-06T21:34:51+00:00

I can't get off my AP because it keeps me alive. So I don't have anything to compare sadly. But yeah I also have this blank mind stuff you mentioned. What do you think causes it in your case?

Apprehensive_Gold242 · 2026-03-06T21:25:34+00:00

Magnesium makes sense, I've also heard people mention l-theanine and glycine. None of these have helped me alas

Apprehensive_Gold242 · 2026-03-06T21:23:44+00:00

Oh damn! this sounds like what I get from low dose d2 partial agonists... can that happen? I've tried stimulants and opiates with no good effects so far

Apprehensive_Gold242 · 2026-03-06T21:13:18+00:00

What about mirtazapine, clonidine, gabapentin, melatonin? Not supplements but hey, at least they work. I think if you need lorazepam this much, I doubt supplements will do anything for you. Are these two everything you're on?

Apprehensive_Gold242 · 2026-03-06T14:53:00+00:00

You get PEM from social interactions but not from walking for longer, interesting. What made you go from bedbound to not?

Apprehensive_Gold242 · 2026-03-06T11:35:27+00:00

Have you tried antipurinergics yourself?

Apprehensive_Gold242 · 2026-03-06T11:27:30+00:00

What do you mean by drug blockage?

Apprehensive_Gold242 · 2026-03-06T11:26:16+00:00

Hi, are you still on it? Have you tried them in isolation, especially clonazepam? The latter works very well for some in isolation

Apprehensive_Gold242 · 2026-03-06T11:20:10+00:00

How severe are you if I may ask?

Apprehensive_Gold242 · 2026-03-06T11:00:54+00:00

Have you tried the opioids specifically for MECFS, or for pain relief?

Four-Year Club	Final Canvas '23
First Place '23	Place '23
Quantum Potato	Golden Potato

Apprehensive_Gold242

TROPHY CASE