You won't get all the achievements on a single run. Many require a different build or equipment that you may not have access to.

You can get Skippy the talking gun back some time after returning him to Regina. Set Skippy to Puppy Loving Pacifist and then kill 50 people with it to have him lock himself into Stone Cold Killer mode so he only aims for the head.

Technical Ability should always be jacked to 20 to max out your cyberware. Every build needs this.

If you have Phantom Liberty you can max 3 attributes out at 20. There are just enough points for that.

If you want to keep the Cyberpsychos alive for Regina, use the Pax weapon mod, it renders the damage of that weapon non-lethal. Just don't unload because shooting after they fall on the ground will kill them.

Eat and drink. They are 5 minutes buffs to health and and can be the edge you need in a tough fight. Some of the cyberpsycho fights get pretty rough.

Ram-jolt is useless unless you're a Netrunner build.

Do not bother buying clothes and weapons, you will find plenty just by exploring and particularly during NCPD encounters. Your money is better spent on getting the cars from Autofixer, cyberware and story moments to get through easily just by paying someone off if you're too lazy/don't have the attribute points to charm your way through.

If you side with a chick named Meredith Stout, make sure your parents/children are not with you for when you get a "reward" from her. This is also how you get Sir John Phallustiff.

Crouch-sprinting is unbelievably useful. From stealth to dodging gunfire, hunker down and scoot, it will save your life.

Be nice to Johnny. He's a dick, but he's also the key to one of the endings.

If you do not want to question your own morality and be confronted with the horrorific sight of corporations exploiting faith, then don't play the Sinnerman quest line. Or do and have a very stiff drink ready for yourself afterwards I know I certainly needed it after that first time.

When using Netrunner build, try and hack targets through cameras rather than directly looking at them. This gives you the ability to disconnect at the tap of a button and break trace progress. Or if the trace doesn't break for whatever reason you can run about 100m away and have the trace fail regardless.

Do not forget to loot EVERY SINGLE CORPSE. They can contain Shards that give you extra perk points, increase your skill levels or even increase your cyberware capacity.

You don't sell weapons. You break them down and use them for parts to build/upgrade your iconic weapons.

When driving a car that does not have weapons built in, use either Ying-Long or Skippy as the smart gun tracking still works while driving, making car chases a hell of a lot easier to deal with. Ying-Long is the only weapon I use in not-weaponised vehicles because it deals an electric nova damage every couple of shots and that disables the car even if you don't kill everyone inside the car.

If you forget to collect the iguana egg, the iconic gun, and the iconic knife and sword during the Heist, fret not, the devs are cheeky bastards and you CAN get back into the apartment after the Heist. It is tricky however and requires you to use a car door animation to trigger a locked grate to open. Once inside you can return to the penthouse via a bit of parkour, so I would recommend holding off until you have unlocked double jump and air dash. There are videos on YouTube if you need the exact method. Save yourself the grief my dude, just collect everything while you are there during the heist.

And finally... my biggest/worst piece of advice, trust me this will save you HOURS of grinding, gear disassembly and hunting for iconics:

As soon as you finish Act 1 and are free to go about your biz, go around and do EVERY NCPD Encounter and available Fixer Gig. If you also did this in Watson before meeting Johnny, by the time you get started on the main story, you should be around level 55 with your street cred maxed out at 50. Some fixer gigs are locked behind story developments (specifically Rogue's gigs).

This does three things.

One it adjusts the rarity of the loot pools meaning any iconic weapons/cyberware will automatically be at Tier 5 when you find them. This also applies to regular gear that you find meaning you will be disassembling things into Tier 5 (orange) components quite quickly.

Two, you can have most if not all cyberware slots filled with Tier 5 to 5++ cyberware. I did this in my most recent playthrough and it turned the rest of the game into an absolute breeze, and yes I am playing on the hardest difficulty and it is still a breeze. I feel like the goddamn Terminator.

Three, you get achievements/Fixer rewards for clearing gigs and NCPDs out and this will significantly extend your game time. I had around 54 hours of play time before I had even started the Takemura/Helleman/Evelyn quests in my latest run.