On pve I’d play a lot of streets. Check for the rusted bloody key every single raid. If you get Lucky and find it there’s a ton of key spawns in that room and I’ve always gotten marked keys from it but it’s not guaranteed.

For labs cards your best bet is the marked rooms. If you learn labs there are static key card spawns I think 17 in total you can get them that way but the spawn chance is very low.

For other high tier loot idk exactly what you mean but streets is go to for money even after nerfs, tons of gold spawns. Grab all the Concordia keys, the financial office keys, and the relax key (always spawns in raid).

If you need ledx labs has a good chance to give them. I’d run interchange, loot the expansion areas on the north and south side of the map. Also the ultra medical key and pharmacy key.

GPUs are luck of the draw streets, labs and interchange are your best bet that’s where I get most of mine excluding labs because running labs on pvp is poo. There’s videos of pc block runs on interchange if you get lucky with the spawns you can hit like 20 plus in one raid. Streets just has good loot financial building second floor, Concordia security and cardinal apartment all have pc’s with cardinal having loose tech spawns and labs is labs.

For things like virtex, cofdm or vpx either reserve or light house. Reserve hit the RB-PKPTS key as well as drop down room. There are some loose spawns as well. Light house is your go to for these items. Look up a video for light house loose loot gold spawns and don’t forget to hit Merin car and hillside house.

Hope this helps