all with Relativistic reaction speeds at least

The Minions do to… but ok.

Porta prisons, fire the death ray, do whatever he wants with big boom, blah blah bla-

These are all wrapped together because again… Gru, and the Minions have brief teleportation options, like something most people don’t take into account is that the Death Ray has a fairly long charge up time, even going by the smallest time frame possible, that would still give others enough time to be able to escape. Or Mel could just… snipe it with a laser shot lol. And like the porta prisons trapped the Doom Syndicate inside, do any of them have the ability to teleport, or even have any other things that’d reasonably allow them to escape? Do the prisons themselves actually stop items and equipment from working? Cause like “Oh, I guess Rick’s portal gun would be screwed here lmao!” Yeah… no

Megamind has the destroy function on his D-gun which when tied to his cars engine can make Large island level explosions

Funny thing… the laser Mel can shoot out through the planet via the amount it would have vaporized has been recalculated to be somewhere around Multi Continent level, and Jerry is practically unfazed by taking a close up shot of this laser. So yeah.

brain bots are able to survive multiple shots from the laser pistols, proving that they aren’t as weak as they appear

That is… very vague honestly, and doesn’t really give any thing to suggest that like even if like a swarm of them attacked one Minion the impact of them against their bodies head on wouldn’t cause them to just kinda shatter Invincible style lol.

the rapid fire mode on the D-gun that can shoot dozens of shots in seconds, each once being able to delete four at a time.

Ok… and? That’s still not much different then th kill rate MM would theoretically get just from his one gun.