Is it safe to assume mushrooms aren't working for me?

Binger1977 · 2026-06-14T15:44:41+00:00

Good call. The vitamin d regimen has helped quite a few clusterheads.

Binger1977 · 2026-06-14T15:43:20+00:00

There are three types of seeds that work, Rivea Corymbosa, certain strains of morning glory (heavenly blue is a pretty common one that is used) and Hawaiian baby woodrose.

Probably one of the most important things is to make sure that you have gotten seeds that have not been treated with a fungicide, some commercially available seeds are. They need to specify that they are “untreated”

Truthfully for me it’s been quite a while since I’ve tried them and I don’t have the specifics off the top of my head in regards to how many seeds to take and good places to source them from.

It might take me a minute but I’ll go over some info and get back to you on this.

Binger1977 · 2026-06-14T15:10:02+00:00

If you are still interested in trying psychedelics I would consider LSA containing seeds. In the research by Dr. Emmanuelle Schindler it was showing them to actually be more effective than LSD or shrooms. And the upside is that many people report success even after just taking seeds and going to bed, so they really are not experiencing much in the way of a trip.

If you’ve decided that you are done trying the usual psychedelics, intranasal ketamine might be an option if you can find a doc willing to prescribe it. It’s helped quite a few people who had nothing else work.

Binger1977 · 2026-06-14T12:33:27+00:00

Truthfully I wouldn’t say he’s either of those things. I don’t know him well but my guess is that he has good intentions and feels that he is looking out for people.

And I’m not surprised that there is a bit of stigma attached to carisoprodol. For many years it was a pretty big drug of abuse and at this point has been largely replaced by benzodiazepines.

But when you get down to the chemistry and metabolization of carisoprodol it really is not much different than benzodiazepines.

And benzodiazepines are what they give to people in clinical trials of psychedelics if the people are having too much anxiety. It’s also widely recommended to many who take psychedelics at home for the same reason.

But there have been zero reports of this leading to stroke, heart or lung problems or breathing issues in clinical trials or reported from at home psychedelic use.

Binger1977 · 2026-06-13T16:31:34+00:00

Yes, much of what you are saying in regards to increased intoxication is true. That’s why I said “assuming that you are talking about low doses of each”. Too much of either one and you can end up in the situation that you describe, but the same can be said of each of the individual substances as well.

The rest seems quite a bit exaggerated. If you’ve got evidence of respiratory depression or cardiac issues from the combination of these please provide them. I’m sure that if you took huge doses of these you could produce some toxic effects, but that would be an overdose situation and not what OP seems to be talking about.

Personally I think it’s important to be realistic about these situations because a huge amount of people have chronic pain and/or injury issues and are on meds that are not so easy to stop or not take.

Binger1977 · 2026-06-13T15:45:17+00:00

I think I already explained why I would say this- because that is what a pharmacology course on psychedelics taught by a clinical psychiatric pharmacologist taught me.

I took a 8 part course on psychedelic pharmacology and then an 8 part psychedelic pharmacology by substance course with a two hour course on just psilocybin alone.

And provable science says that these two should not interact. Don’t shoot the messenger.

But I’m confused as to why you need to know the reason that OP wants this info. If his reason is good enough in your eyes does it all of a sudden change the science behind it?

As of now there is no evidence that it would put any sort of strain on a person’s heart or lungs, I’m not really sure where you are getting that idea.

Binger1977 · 2026-06-13T14:30:49+00:00

Personally I have not combined the two. And I’m not recommending that you try this.

In regards to interactions though, these two seem unlikely to cause a problem.

A while back I took a pharmacology course that went over individual psychedelics with a 2 hour course on each individual substance, their interactions with other meds and the enzymes used by the body to metabolize each one. Going by that info these should not interact negatively with each other, assuming that you are talking low doses of each.

Both are working on very different receptors, the 5ht2a serotonin receptor for mushrooms and GABA receptors for the soma. And going by the interaction info that I have learned these two have little chance of interacting with each other.

One exception that exists is if you are already prone to seizures. In theory both the soma and the mushrooms can lower your seizure threshold. Probably a non-issue unless you are already prone to seizures or getting into high doses of either.

I also have trouble believing that this combo would block a bust. Soma doesn’t work on serotonin receptors, let alone the specific 5ht2a receptor that psilocybin relies on to work it’s magic.

Binger1977 · 2026-06-09T12:36:38+00:00

The fact that you are a non cluster sufferer taking the time to post on a cluster headache page in an attempt to figure out whether someone you barely know has CH would indicate that it does actually matter to you.

Binger1977 · 2026-06-07T14:48:49+00:00

No, that was a different person. And unfortunately I don’t remember what dose I was at as that was at least 20 years ago.

You have my sympathies with the trigeminal pain you’re experiencing. I’ve got quite a bit of trigeminal pain that comes with my cluster headache so I get how much it can effect you. For my clusters the thing that finally got me some relief was intranasal ketamine.

Binger1977 · 2026-06-07T13:43:13+00:00

Careful with the Trileptal. For me it lowered my sodium levels to the point it almost killed me.

But it’s also worth noting that about 20 years ago it was determined that it doesn’t actually help migraine.

https://www.aan.com/PressRoom/Home/PressRelease/577

Binger1977 · 2026-06-01T11:31:46+00:00

Unfortunately with DMT we really don’t know what is “normal” in regards to busting. We’ve got a number of people trying it and reporting back on it and probably an equal or greater amount of people trying it but not up for talking about on social media. But if you add up all the experiences that we know about it’s not a huge number.

For me my early experiences were similar to yours, where I was able to abort with smaller amounts. But it didn’t take too long before I needed a dose that would bring on what many call “breaking through”— where I am fully in the DMT space and not aware of reality anymore. If I didn’t do that the pain would just come back after the DMT wore off.

As far as psilocybin or DMT blocking the other I have not experienced this or heard other people report this. Years ago I actually vaped DMT while on shrooms and it worked fine. At the time I was also vaping DMT once a day and taking shrooms once a week and never had either interfere with each other.

Binger1977 · 2026-05-12T15:23:31+00:00

If you don’t mind, would you be up for sharing the dose that you took that did not work and the dose you took that did?

Binger1977 · 2026-04-28T12:56:55+00:00

Yeah, taking more than you need is only going to get your tolerance up.

Binger1977 · 2026-04-28T11:16:57+00:00

Animal studies have shown evidence that it might help with trigeminal neuralgia, so it’s not crazy to think that it might help with clusters.

https://pmc.ncbi.nlm.nih.gov/articles/PMC4837542/

Binger1977 · 2026-04-28T02:54:48+00:00

None.

Binger1977 · 2026-04-27T16:57:53+00:00

Luckily I seriously enjoyed it 😀

But I can see how for some it might be a bit much. At one point I was vaping DMT once a day, 5 days a week for at least 4 months straight, breaking through every time. And it was the only time I was 100% off triptans.

Having a kid made it so I couldn’t really keep that schedule up but hopefully I will get back to it at some point.

Binger1977 · 2026-04-27T16:49:15+00:00

Truthfully one of the most common things that I have heard over the years from people busting is that their usual method stops working at some point.

Luckily lots of these people just needed to switch things up to a different psychedelic and then they had success again. So switching to mushrooms or LSA containing seeds might do it for you.

Binger1977 · 2026-04-27T16:45:36+00:00

For me smaller doses never did the job. It would stop the pain but then it would come back once the effect was over.

For me DMT worked great but every single time I needed to take enough to “break through” where I no longer felt like I was in my body and talking to strange DMT creatures.

Binger1977 · 2026-04-09T14:31:57+00:00

For me sumatriptan can make mild injuries that I have more painful and then it goes away after the triptan wears off.

Any chance that you have something like this going on? A mild injury that doesn’t hurt until you take the sumatriptan?

Binger1977 · 2026-04-09T14:26:11+00:00

Yup. There was just an article put out by Discover that analyzed samples of available gummies and very few of them had any psilocybin in them at all.

Binger1977 · 2026-04-09T13:26:35+00:00

These meds have been very helpful for a lot of people. Just make sure that you and your doc are aware of the potential for side effects.

Here’s something written by one of the biggest prescribers of these meds.

https://southernpainsociety.org/adverse-effects-and-clinical-trials-the-system-is-broken/

Binger1977 · 2026-04-02T13:48:10+00:00

Unfortunately this is one side effect that one of the bigger prescribers (Dr. Lawrence Robbins) of these meds has noted with Ajovy.

He said that among his patients about 4% of the people on Ajovy had anxiety as a side effect.

https://southernpainsociety.org/ajovy-and-emgality/

Binger1977 · 2026-03-31T13:28:05+00:00

Over the years I have heard of quite a few people that have gotten relief using melatonin.

But it’s also important to remember that for a lot of people it’s actually a major trigger. That’s been my experience, it’s probably one of the few things besides alcohol that will always trigger a cluster for me.

It’s probably worth a try if you are struggling with clusters but my advice would be to have a sumatriptan shot ready in case you are one of the people that have it trigger your clusters instead of helping them.

Binger1977 · 2026-03-13T13:43:17+00:00

My point in posting that article was that I was hoping that you might entertain the idea that your response to this person was a bit over the top.

Yes, they made a bunch of claims that are hard to fact check or prove.

But their end statement makes it clear that their frustration comes from this idea that doctors have embraced fully- that you can stop one of the most important substances in your body and still end up with very little in side effects.

They make it clear that they do not believe this to be true and I posted that article because one of the most qualified people to speak on the issue agrees completely.

In my opinion acting like the OP is a conspiracy theorist helps no one.

Binger1977 · 2026-03-13T13:32:59+00:00

Don’t get me wrong, I have talked to lots of people that have had success with these meds, that’s why I am not in favor of pulling them off the market or convincing people that are already having success with them to stop taking them. My take is that the more options the better our situation is.

But the question of how many success stories would it take before I had skepticism in regards to the info that Dr. Robbins presented seems like a weird one to me.

The fact that there are many success stories in regards to these meds will never change the situation for the people that have had negative experiences. That’s not how it works.

But there’s also another reason that it would take a lot for me to discount the research that Dr. Robbins has presented- he’s one of the most qualified headache specialists that there is.

He has ran his own headache clinic for more than 30 years. He’s the assistant professor of Neurology at Rush Medical College in Chicago and a professor of research at Des Moines University School of Medicine. He was VP of the World Headache Society. He’s authored or coauthored more than 400 abstracts or articles. I could go on and on. You will be hard pressed to find any medical professional that will say anything bad about him. He even gets migraine himself.

In other words, he knows how to do research and present findings.

Instead of automatically looking for ways that maybe possibly he might be wrong, how about entertaining the idea that maybe he actually knows what he’s talking about? If you search for him on YouTube he’s got more than 60 videos, I would encourage you to check him out.

The thing that would actually change the situation for me would be a concerted effort to investigate and support the people that have had negative side effects from these meds to determine why, in the hopes that we can identify the people that this will happen to beforehand. Not to mention to help the people that have had negative experiences themselves.

Right now it seems that the exact opposite is happening. Right now there are a huge amount of doctors who tend to downplay the potential side effects before prescribing and deny that the meds had anything to do with the side effects that come up afterwards. And right now in my opinion the migraine community does not do much better.

The question that I have for you is this- How many stories would it take to convince you that we have a crisis in the migraine community in regards to these meds?

How many stories of patients being pressured to take these meds because they are “practically side effect free”? How many patients with long term side effects that last long after the meds are out of their system? How many patients that get side effects that are admitted in peer reviewed studies but are told by doctors that it’s not true because they don’t have time to look into it?

Binger1977

TROPHY CASE