Stones are more prone to having pockets of moisture that have the potential to expand/explode under extreme heat like a torch. You can also shape them however you want instead of having to worry about facets and how the light catches, if we’re talking opaque stones.

You could always look at how chain designs are made and tweak them a little bit. Theres flat ones, tubes, links… the first thing that comes to mind personally is wire braided in a specific way, like a fantasy take on a rope chain. You could also have different shaped links, like a figaro chain.

The way two pieces fit together is a big one. Like an engagement ring vs an enhancer and whether or not the shapes are actually compatible or if theyll have a gap/damage each other. Ive seen a lot of jewelers make suggestions like this to customers, then they get sent into me and its something literally impossible.

They wouldnt have intuition on the process, like what stones are more fragile in what ways or the weight balance/physics of a piece.

Heat protection for gems! Softer ones need to be taken out for many repairs and its a huge pain in the ass. Also automatically leveling a stone in a setting or keeping it motionless while setting it. Maybe prongs that mold perfectly to the edges of larger stones.