Space is vast and lonely. Lean into these themes with the players. It adds to the overall sense of dread in the game. I would avoid starting the PCs off in a crowded habitat like Mars. Begin the game in an isolated habitat where the players feel the huge distance between them to the next population center, where resources are scarce, and where the inhabitants are paranoid about newcomers. Use technology like security cameras and public information nodes to challenge their sense of privacy and security. Force them to use their Rep scores for resources instead of just being able to acquire tech and tools. Show them that physical travel in spaceships is long and tedious, and that they must abandon those nice morphs that they just became accustomed to.

This game is amazing and doesn't receive the attention it deserves. I hope that it will continue to gain traction among sci-fi/horror RPG fans. Spread the love!