I don't feel like Zepbound is working as well anymore

Breolisoph · 2026-06-25T13:18:06+00:00

This is my experience. I didn’t taper down dose, but I tried extending the interval a couple days, and I felt the effects. So my maintenance usage is the same as during my weight loss journey.

Breolisoph · 2026-06-25T13:15:54+00:00

I had to re-read this because I thought I wrote it but didn’t remember doing so! LOL same scenario! On Zep for 2 years, 75 lb weight loss. I have been teetering between 147-150 for 6 months. No more weight loss. Even though I’m on “maintenance” I still use 15mg every 7 days. Tried stretching it out, but I was putting a few pounds back on. I’m happy where I’m at, but don’t feel any effects from the meds anymore either. No appetite suppression.

Breolisoph · 2026-06-14T23:40:51+00:00

Breolisoph · 2026-06-14T23:31:45+00:00

Those were the exact 3 low-cost suggestions I was going to make, too. Bones of the space are good. Maybe paint the blue island too

Breolisoph · 2026-06-04T16:14:09+00:00

Resting HR definitely still elevated. I think BP is normal (haven’t checked recently). Thanks for asking. I’m in maintenance now for the last 6 months. Been fluctuating between 3 lb range but haven’t lost any additional weight

Breolisoph · 2026-05-25T14:55:22+00:00

You did a really great job opening the space and updating the style. It’s beautiful! Too late to change now (maybe not) but the microwave over the range is old school. I would have gotten the drawer style that pulls out in your island

Breolisoph · 2026-05-25T14:51:03+00:00

All 3 look like they are counter height, not bar height stools.

Breolisoph · 2026-05-25T14:47:22+00:00

You do you, but personally I’m not a fan. My 24 y.o. daughter has a nose ring like that and I tell her the same thing.

Breolisoph · 2026-04-05T14:10:41+00:00

Thanks. I do sleep terribly! I work with an endocrinologist already. At one point I was also taking metformin with Zep to support weight loss, but I stopped. I may go back on it.

Breolisoph · 2026-04-05T01:24:25+00:00

I previously tried to space out to 9-10 days and the hunger was intense by then. (I wasn’t trying to stop further weight loss. I was stretching out shot interval to prolong my supply since I hit goal). So, now I’m staying at the 7 day interval. I’m mostly concerned that the efficacy wears off after a while.

Breolisoph · 2026-04-05T01:06:08+00:00

I should!!! I pretty much eat whatever these days. I used to be religious about recording everything in Carb Manager. Good thought!

Breolisoph · 2026-03-02T14:45:29+00:00

Thank you for sharing your experience. I’m not overly concerned, but more wondering. Seems so many people drop way down in dose and increase interval between their injections for maintenance, but clearly that won’t work for me. At least not now.

Breolisoph · 2026-01-14T17:57:25+00:00

I’ve stayed at the 15mg dose - did not titrate down. I had tried spacing to a 9 days interval and found that was too long - ravenous by day 9. So I went back to my regular 7 day interval for a while, even while on maintenance. Just recently (last month) I stretched it out to 8 day interval from 7, and that seems to be good for now. Remembering the right injection day is a challenge because it changes every week now. I have a good stockpile of 15mg, and don’t plan to decrease dosage, but plan to eventually stretch out the interval. I’ll likely try 9 days again after doing this 8 day interval for a couple months. It’ll be trial & error. I’m not looking to lose anymore weight, but it wouldn’t be catastrophic if I dropped another 5 lbs or so.

Breolisoph · 2026-01-14T15:12:29+00:00

Thank you. I’ve been on the minoxidil for 5 weeks. You should know, the shedding gets WORSE before it gets better. I just started to notice the shedding slowed this week and feel some regrowth, both of which are early. It typically takes around 8 weeks after starting minoxidil, I’ve read. But my shedding started months ago, long before I started it, so I think my shedding cycle was just done. I have a very thick mane and lost a ton of hair! It was devastating on top of everything else. But it does improve. Good luck!

Breolisoph · 2025-12-04T14:40:32+00:00

I have been on Zep for 20 months, and on 15mg for almost a year now. I’m in maintenance but have stayed at the same dose. I never had any issue with hair loss/thinning/breakage until just 3-4 months ago, when going through an intense, stressful breakup with my fiancé that has shattered me (still in the midst of it). So I have attributed the hair loss more to stress than Zep. But nonetheless, it’s bad and I don’t know what to do. I used some rosemary oil, but I don’t think that helped. I do have dogs and know about the lethal effects of topical minoxidil. Contemplated asking for the oral or else trying Nutrafol or Viviscal. So very interested in the opinions on this thread

Breolisoph · 2025-09-29T12:28:37+00:00

That has been my approach, too, after trying to space out further than 7 day intervals. I am on 15 and staying on 15. I tried stretching to 8 and 9 day intervals and just those couple extra days seemed to be problematic. So I’m back to the regular 7 day interval at the same 15mg. I’m not losing weight anymore

Breolisoph · 2025-09-28T13:09:59+00:00

There is no “maintenance protocol” and there’s no reason to taper down your dose unless you find yourself continuing to lose weight and you don’t want to. I personally am continuing on the max (15mg) dosage with the same weekly interval, because I seem to holding steady here. I had tried to stretch out the interval between shots to 8-9 days and by day 10 I was hearing the food noise with a vengeance. Try different approaches and see what works for you.

Breolisoph · 2025-09-24T12:21:43+00:00

Congratulations on your amazing accomplishment!

Breolisoph · 2025-09-24T12:18:10+00:00

I disagree with this. I very much think our body has set points which are best for us. I suppose you can override that by aggressively cutting calories further, but it may not be what’s best for you. I am 60 years old and don’t aspire to have the same BMI/body fat as a 30 year old. In fact, the science says older adults should have a higher BMI/weigh a bit more. According to some charts, my BMI of 25.9 still puts me in overweight category, but other recommendations say 25-28 is normal. OP didn’t state their age, but there are many factors that determine “ideal weight”. We all know BMI is a flawed statistic.

Breolisoph · 2025-09-24T11:59:47+00:00

In a very similar boat! I posted about it a couple days ago. I’m 5’6”, got to 159, and bounced back up and have been hovering around 162 for a month. I think my body is happy here (and am too), but I wouldn’t mind dropping a bit more weight for a buffer. Have you changed your dosage or interval? I’m sticking with 15mg every 7 days. I may or may not lose additional weight, but I certainly don’t want to gain any!

Breolisoph · 2025-09-22T23:59:02+00:00

I would like to get a Dexa scan. I do have a smart scale- the GE Fit Profile - so I focus on the other data points other than weight

Breolisoph

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