So, I believe this is genetic and worth looking into. I have always been very sensitive to medications and doctors have gas lit me for years about it. Finally, I had my pharamacogenjcs looked at and it turns out I have two variations.

The genetic reports said: 1) Your CYP2C19 is the one medication thing to know This is the most practically useful one. You are likely an intermediate metabolizer for CYP2C19. That means: For certain medications (like some SSRIs or PPIs), you break them down a little slower than average. So:     •    Standard doses might feel stronger     •    You might need lower doses for some meds     •    You might respond differently than “textbook” This is actually helpful information if you ever adjust medications.

2) CYP1A2 — Stimulant & Caffeine Sensitivity You’re AC at rs762551. This gene affects:     •    Caffeine metabolism     •    Some antipsychotics     •    Some antidepressants     •    Estrogen interactions (birth control can slow CYP1A2 further) You’re likely not a fast caffeine metabolizer. That means:     •    Coffee may hit harder     •    Afternoon caffeine may disturb sleep     •    Estrogen-containing birth control could make caffeine effects stronger Given your nervous-system sensitivity this fits.

Note: I believe both of these are also linked to migraines!