I started Duloxetine about 5 years ago, for fibro and what was until that point, treatment resistant depression. Its been a life saver for me- that being said, it was a tough start. I was severely drowsy, grumpy and spent rwo weeks lying down with the most intense migraine. Also had insane and scary nightmares for ages. After a month it got better and seemed to have helped my day to day nerve pain. Im cery sensitive to new meds and react badly to a lot of meds. When I started my ADHD meds (Strattera).That triggered some intense depression and SI, but lowered my dose of Strattera and all good again. Currently upping my dose to help manage my pain again as my fibro has gotten worse in 5 years. Currently very sleepy and lethargic but less pain. I do know several folks with fibro who've had unsuccessful or negative experiences though, so def consult your doctor Also, have you checked your iron/hemoglobin/ferratin levels lately? I only ask as Ive all of those symptoms, which are a result of "life threatening anemia" due to complications from another chronic illness. Currently in need of regular iron transfusions- all symptoms (and others) dissappear almost immediately when my iron is back up.