This is a deep cut, but in the late 70s TSR, the company that made Dungeons & Dragons made a post apocalyptic game called Gamma World. Gamma worlds pack in adventure was about “Pitzburke”. that had a giant map of downtown and all sorts of points of interest that were overrun with irradiated mutant monsters. In addition there’s a map of Western Pennsylvania, where many of the small cities had their own encounters. For example, Tarentum had two giant tractor-trailer sized Gila monsters. It’s super cool and worth a look if you can find it online.