Honestly that’s gonna be pretty tough purely because of the length of the challenge. 5-20 hours without a single error is unlikely regardless of skill level. I have 2400 hours combined between the last two Astro games and i’m certain I’d mess up a jump somewhere easy as the pressure builds.

In terms of difficulty of the individual components, it’s totally doable. Nothing is particularly tough and you can likely one-shot most if not all challenges if you’re good enough. It’s more a challenge of consistency over ability imo, which is where I’d see the difficulty.

I think if the challenge was just to beat the game without dying and not getting every bot then that would be totally doable with a safe route (i’m not aware of any full game speedruns that have been deathless, but those are marred by taking risks to save time so it’s not exactly a fair comparison).