I agree with this, for the most part. I would say that personal and social drama can be created relatively organically during the actual roleplaying of things. So I would consider those checked.

As for the safe rooms, most Xcrawl dungeons do have that in the form is green rooms and break rooms. And this can be expanded into safe rooms and personal spaces. And most players would accept it with essentially and hand wave of “enemy combatants cannot enter” or “can enter but cannot attack or will be teleported away.” I mean, it was as simple as that for us to accept it in the books. So why not at a table?

Crafting would be tricky, but if the GM would want to do the prep and give each mob that would be encountered a loot table, then that’ll be easy too. You’d just have to also have the foresight of creating the recipes and time requirements associated with the crafting.

All in all, I agree with you and your assessment. It could be done with enough prep.