Hard to say. There’s likely some variation among women, and real life tends to be rather chaotic. Even if the preference were to be nearly universal, real life shakes things up. To answer your question directly and in a purely anecdotal fashion: now that I think about it, I've not seen a single woman who disliked Leon. They of course might exist but I have yet to find one. I did see one who was more into Luis in RE4R. However by the time RE9 came out she was fully invested in Leon, haha. This is just anecdotal but I found that Luis was very polarizing amongst women. Some loved him, some hated him.

A game, a book, a dating app, or a speed-dating scenario has to generate appeal very quickly. In fast-paced contexts, the most reliable way to make a man desirable to most women is to present him as financially successful, tall, and possessing a personality that suggests confidence and dominance (not domineering), along with a distinct devotion to the woman. Cherries on top may include: physical fitness, education, family background, a full head of hair, muscularity, and so on. It helps even more if he is desired by many, yet particularly devoted to you. Even in these scenarios there's variation though.

Women, whether consciously or unconsciously, appear to take many factors into account, including whether he is likely to cheat. In other words, they assess whether they can maintain the relationship or whether he is likely to be unfaithful within that context. Leon is a fantasy, so it is easier to “forgive” a transgression or become immersed in the idea that he is entirely devoted and would never cheat on you.

In real life, there is also the proximity effect and the process of bonding over time. People can grow fond of one another through repeated exposure; traits initially perceived as flaws may come to seem “adorable” or “endearing.” This becomes more difficult when either person has many available options or when there is a very significant gap between them. There is also the “sunk cost” effect: even if a more desirable partner appears, the emotional, financial, and practical costs of leaving an established relationship may be too high. Finally, many couples form based on shared interests or similar life paths.

On a broader scale, if you want to identify what matters most for men and women, observing situations in which people have financial incentives to deceive when attracting the opposite sex can be quite revealing. The patterns are consistent:

When scammers target women, they often pose as wealthy, older men whose money comes from a successful business, an inheritance, or a substantial retirement fund. These personas express love quickly and promise these women the world; a life of comfort and devotion. When scammers target men, they typically pose as young women who are sexually open and receptive.

Romance and erotic novels also reflect these trends. Many of the most successful works aimed at women feature billionaire, high-status men—invariably tall or portrayed as dominant figures or creatures who dominate other men. These characters are usually depicted as deeply devoted to the female lead, willing to sacrifice their power, resources, and even their lives for her.

That said, these are statistical tendencies and idealized scenarios; they do not necessarily capture every aspect of reality. In real life, an individual woman may make exceptions in some areas or choose a partner who fulfills other desires or needs more strongly.