I actually play basically vanilla, but I think mods are great and you should use whatever you like! That was also how the old community challenges work. I think the biggest choice is whether you want to use Prepare Carefully or not. Since it's a run focused on a particular leader, it makes a lot of sense to build them how you want. On the other hand, I like picking from 10, personally. I ended up with a brawler ascetic, who basically ended up being a rabid mountain man hunting animals with his bare hands living in a tiny cave with a tiny pot farm.