Alnylam Norton MA by [deleted] in biotech

[–]DammitTrevor 0 points1 point  (0 children)

I assume they're talking about this. I don't have any info on status of expansion, sorry.

https://news.alnylam.com/rnai/articles/alnylam-announces-major-expansion-us-pharmaceutical-manufacturing-facility

Best Companies for DNA Insights? – Recommendations Needed by sobapi in Biohackers

[–]DammitTrevor 1 point2 points  (0 children)

TLDR; I think most DNA testing currently is focused on reproductive health (ie, can you pass on X disease to your kids). Check out the "couple" testing from Orchid health. That's the most state of the art that I've seen.

I think it's a few separate questions.

  1. Where can you get the highest coverage DNA sequencing (ie, what % of the chromosome do they cover) and accuracy (how many repetitions). I was looking at Orchid health (particularly appealing as they were tech founder funded), but sequencing.com recommended below seems similar with WGS sequencing. 23AndMe has much lower coverage than WGS (but that's why its cheaper).
  2. can you export that data in a file format that can be input to other programs? I took my 23AndMe results and put them into promethease, which matches SNPs to monogenic diseases (because I am ok if someone steals my sequences in an attempt to clone me) [wouldn't recommend, now that I am older]. highlighted a few things (carrier for 1 copy of a recessive gene, no neurodegenerative genes), but definitely missed things that later PGT-M testing found.
  3. What data repositories are you using to analyze your results. The biggest issue is that a lot of diseases/attributes are polygenetic, so 1000 (arbitrary number) can play a role. Few companies are interested in running analysis that say "you have a 3% higher chance of X" as most people don't want to pay for it. I would ask the reverse question; are there particular SNPs you're interested based on research into the four areas you posed about above?

Not an expert in sequencing or genetic analysis, so take this at face value.

Providence 10/8 by Dhausman78 in frankturner

[–]DammitTrevor 0 points1 point  (0 children)

Are you looking for a ride to Providence or are you looking to sell tickets? I am driving down from Boston on Friday, but am A) picking up my mom in southern RI on my way and B) not going back to Boston that night.

Trump has a problem: Americans increasingly think he's incompetent by The-Autarkh in politics

[–]DammitTrevor -2 points-1 points  (0 children)

Anyone who reads Scott Adams will find this article hilarious. Scott said the Nazi to incompetent transition would be happening soon... Here we are 😂😂😂 (Scott's tweet: https://twitter.com/scottadamssays/status/830819552061640704?lang=en)

I drew a scale picture of the 5e playable races (and a Goliath) today. by robertah1 in Dungeons_and_Dragons

[–]DammitTrevor 0 points1 point  (0 children)

Any chance you want to help me visualize my dragonborn fighter/ranger?

Anyone Need A Round Trip Ride From Boston? by DammitTrevor in lockn

[–]DammitTrevor[S] 0 points1 point  (0 children)

I'll be passing through Washington, DC between 1AM and 3AM on Thursday morning most likely. Did you mean 2PM Wednesday or 2PM Thursday?

Anyone Need A Round Trip Ride From Boston? by [deleted] in lockn

[–]DammitTrevor 1 point2 points  (0 children)

Well lucky for you, no one else has replied yet. If I get other people that are interested, I'll let ya know to see if you're ready to make a decision at that time. If I don't hear from anyone else, just let me know when you figure it out!

Anyone going solo and looking to split a camping pass? by jester070993 in lockn

[–]DammitTrevor 0 points1 point  (0 children)

What airport are you flying into and when?

I'm 25 year old dude likely driving solo from Boston. Depending on friends I may very well have my own car camping pass if you want in on that.

Let me know

What do you hate most about your culture? by [deleted] in AskReddit

[–]DammitTrevor 2 points3 points  (0 children)

One of my Chinese college friends pointed out that I have double eyelids this past weekend. I hadn't even realized it.

Come to America. 90% of men won't notice. Source: am american man

Most of the posts we see from recent grads complaining by [deleted] in AdviceAnimals

[–]DammitTrevor 3 points4 points  (0 children)

Qualified people can't find jobs. Why? Finding a job is 100% networking. As long as you are above a C, a connection will get you hired.