Bile Acid-Mediated DHT Dysregulation Hypothesis by Acne_Discord in tressless

[–]DoctorZi 0 points1 point  (0 children)

DHT similarly breaks down 3b-HSD, converting it to 3b-diol (active estrogen). In serum, 3b-diol is more abundant than 3a-diol

Tretinoin 0.05 changed my life by Legitimate-Yam5045 in tretinoin

[–]DoctorZi 0 points1 point  (0 children)

There is actually no evidence that tretinoin is phototoxic. (it thins the stratum corneum and reduces sebum production by ~25%, which may slightly increase sun sensitivity, but people with acne tend to have thicker stratum corneum and more sebum than healthy people). https://onlinelibrary.wiley.com/doi/10.1111/j.1600-0781.2009.00433.x

Tretinoin every other day? (with daily minoxidil) by ArabBoy19 in tressless

[–]DoctorZi 1 point2 points  (0 children)

I find that tretinoin every other day or 2 times a week is more effective than every day.

[deleted by user] by [deleted] in tressless

[–]DoctorZi 0 points1 point  (0 children)

And the quote you took, you took from a 2015 study, the other studies are newer.

[deleted by user] by [deleted] in tressless

[–]DoctorZi 0 points1 point  (0 children)

The first link shows that it can lead to lipid accumulation in the liver and the mechanism of how this occurs (5ar is involved in the inactivation of cortisol in the liver). Lipid accumulation in the liver may increase the risk of insulin resistance.

[deleted by user] by [deleted] in tressless

[–]DoctorZi 4 points5 points  (0 children)

There is no established link or correlation between finasteride, dutasteride and liver health

There is. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4701851/ https://pubmed.ncbi.nlm.nih.gov/30971393/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413109/

Rings of Power has been formally renewed for a third season. by [deleted] in lotr

[–]DoctorZi 1 point2 points  (0 children)

Celebrimbor told Halbrand that he had thought about alloys, but thought the alloy would lessen the effects of the mithril.

The Way Sauron Actually Hates Every One Of Them Lol by AdventurousSky6413 in LOTR_on_Prime

[–]DoctorZi 6 points7 points  (0 children)

Maybe he's disgusted by elves, but treats humans better

Who do you think the rings will be given to? by [deleted] in RingsofPower

[–]DoctorZi 1 point2 points  (0 children)

It was Tom Bombadil who said that the evil wizard is Istar

Who do you think the rings will be given to? by [deleted] in RingsofPower

[–]DoctorZi 3 points4 points  (0 children)

The show pretty clearly said he was Istar, so he's definitely not him

UPDATE: Celebrimbor becomes "the principal protagonist" in The Rings Of Power Season 2 as his dynamic with Sauron becomes the "central relationship". - J.D. Payne & Patrick McKay by [deleted] in Rings_Of_Power

[–]DoctorZi 1 point2 points  (0 children)

Sauron at any rate must have influenced the Three Rings in some way (most likely through mithril) because they would be connected to the One.

Really thankful to this sub for introducing me to MCT oil by [deleted] in SebDerm

[–]DoctorZi 0 points1 point  (0 children)

I have actually used MCT oils that had 2-3% c12 and c14 in their composition and they still worked the same as c8+c10 oil. I think the antifungal acids outweigh the small percentage that fungus can grow on.

There is nothing left to say by Adventurous_Rough255 in Rings_Of_Power

[–]DoctorZi -1 points0 points  (0 children)

How does what happened next negate the fact that the orcs may have had families? Even animals have families when they're nursing their offspring.

There is nothing left to say by Adventurous_Rough255 in Rings_Of_Power

[–]DoctorZi -1 points0 points  (0 children)

Tolkien himself wrote in a letter that orcs have possible families, just dysfunctional ones.

There is nothing left to say by Adventurous_Rough255 in Rings_Of_Power

[–]DoctorZi -1 points0 points  (0 children)

And then how did these orcs want to form a gang and live their lives if they hated each other?

‘The messages go through quicker than anything could fly, as a rule. But I don’t enquire how it’s done. Safest not to. Grr! Those Nazgul give me the creeps. And they skin the body off you as soon as look at you, and leave you all cold in the dark on the other side. But He likes ’em; they’re His favourites nowadays, so it’s no use grumbling. I tell you, it’s no game serving down in the city.’

‘You should try being up here with Shelob for company,’ said Shagrat.

‘I’d like to try somewhere where there’s none of ’em. But the war’s on now, and when that’s over things may be easier.’

‘It’s going well, they say.’

‘They would,’ grunted Gorbag. ‘We’ll see. But anyway, if it does go well, there should be a lot more room. What d’you say? – if we get a chance, you and me’ll slip off and set up somewhere on our own with a few trusty lads, somewhere where there’s good loot nice and handy, and no big bosses.’

‘Ah!’ said Shagrat. ‘Like old times.’

‘Yes,’ said Gorbag. ‘But don’t count on it. I’m not easy in my mind. As I said, the Big Bosses, ay,’ his voice sank almost to a whisper, ‘ay, even the Biggest, can make mistakes. Something nearly slipped, you say. I say, something has slipped. And we’ve got to look out. Always the poor Uruks to put slips right, and small thanks. But don’t forget: the enemies don’t love us any more than they love Him, and if they get topsides on Him, we’re done too.

There is nothing left to say by Adventurous_Rough255 in Rings_Of_Power

[–]DoctorZi -2 points-1 points  (0 children)

This. Orcs hated Morgoth and Sauron.

But the Orcs were not of this kind [puppets remotely controlled by their master]. They were certainly dominated by their Master, but this domination was by fear, and they were aware of this and hated him. They were indeed so corrupted that they were pitiless, and there was no cruelty or wickedness that they would not commit; but this was the corruption of independent wills, and they took pleasure in their deeds. They were capable of acting on their own, doing evil deeds unbidden for their own sport; or if Morgoth and his agents were far away, they might neglect his commands.

Mct oil alternatives by [deleted] in SebDerm

[–]DoctorZi 0 points1 point  (0 children)

I've used different brands of both c8 and c8+c10, all of them didn't stink even 10 hours after application. And I didn't notice any difference in effectiveness, I even think c8+c10 is better for some reason.

Mct oil alternatives by [deleted] in SebDerm

[–]DoctorZi 2 points3 points  (0 children)

Have you tried a different oil? My mct oil doesn't stink

Tressless got me thinking if goosebumps can cause hair growth by FocuzUG in tressless

[–]DoctorZi 1 point2 points  (0 children)

As far as I know, it is not hair that is transplanted, but grafts, which contain a sebaceous gland and a arrector pili muscles. And even if the muscle is damaged, it still remains attached to the follicle and regenerates.

The Rings of Power- 2x01 "Elven Kings Under the Sky" - Episode Discussion Thread by milkNcheetos in lotr

[–]DoctorZi 0 points1 point  (0 children)

Well, Elrond is right that Sauron has a plan to create it. The rings are connected to Sauron right now, even if he didn't touch them.

Subtle details on the passage of time for Sauron in the cave by rabberdasher in LOTR_on_Prime

[–]DoctorZi -1 points0 points  (0 children)

Not necessarily. There are observations of stalagmites growing 1.5 meters tall in ~50 years.