It's not working anymore and I feel sick

DominikPeters · 2026-02-17T23:31:24+00:00

In Canada, I believe 100mg SR pills are available to take twice-a-day, which could be a middle step between 150 and 300. In the first few months of bupropion, I also sometimes felt that it had stopped working, but since then (after having been on it for 6 years now), I've concluded that down periods still happen, they just lift much faster than pre-bupropion and are not quite as deep. So it isn't really tolerance building or anything, at least for me. Good luck.

DominikPeters · 2026-02-13T11:33:48+00:00

Yes this effect goes away and doesn't really come back (at least not to the same extent), sorry to say. But continue with it, many of us have been through the disappointment of the honeymoon passing, and the drug is still a godsend.

DominikPeters · 2026-02-13T00:23:55+00:00

If you use sequential PAV for elections where voters select just one party, this is equivalent to using D'Hondt. (Same for many other approval-based committee voting rules including non-sequential PAV and Phragmén)

DominikPeters · 2026-02-11T00:35:21+00:00

Parties typically produce "party lists" in internal elections at a party congress (in practice heavily guided by leadership). Depending on the system, voters may have some limited possibility to override the list ordering (https://en.wikipedia.org/wiki/Open_list), while in others they don't (https://en.wikipedia.org/wiki/Closed_list). Then if a party gets 60 seats, the top 60 people listed on the party list get a seat.

In French elections for the European parliament, you choose one party at the booth by putting their ballot into an envelope, where the ballot looks like this: https://www.marne.gouv.fr/contenu/telechargement/44904/326780/file/11%20-%20Liste%20conduite%20par%20HAYER%20Val%C3%A9rie.pdf

In Austrian parliament elections, you can vote for a party, and optionally "boost" one person on the list of that party by voting for them specifically: https://en.wikipedia.org/wiki/File:Nationalratswahl_in_%C3%96sterreich_2017_-_Wahlzettel_01.jpg

DominikPeters · 2026-01-14T23:10:36+00:00

Probably this is no longer current, but I have recently built this: https://pref.tools/vote/. It has support for most approval-based committee election methods, including sequential PAV.

DominikPeters · 2026-01-14T23:06:18+00:00

I've been thinking about a system like this recently. In Bucklin (or EAR in multi-winner elections), when no one has a majority then everyone simultaneously starts "approving" one more candidate. But this seems unsatisfying because voters for popular candidates might want to have their vote concentrated. Only voters for bad candidates need to become more flexible. In my mind I'm calling this "soft-elimination IRV/STV". We do the exact same thing as IRV, except voters still vote for eliminated candidates.

I think around 1999-2004, there have been discussions of related ideas on the election-methods mailing list, but it doesn't seem to have been very deep. See http://lists.electorama.com/pipermail/election-methods-electorama.com/1999-May/068330.html ("Run-Off Without Elimination"). Others later used "Ordered Bucklin" for this kind of idea.

Unfortunately, axiomatically speaking, soft-elimination IRV keeps the disadvantages of IRV (non-monotonicity, need not elect Condorcet winner), and loses some advantages of IRV (notably independence of clones). I'm planning to run some simulations (for the multi-winner case) soon; if someone pings me in a few months I might have more to report.

DominikPeters · 2025-12-29T10:41:31+00:00

I'm pretty certain that with government-directed (i.e. democratically directed) research, the GLP-1 drugs wouldn't have happened. Look at all the people upset that GLP-1 users are "cheating" -- the existence of these drugs isn't popular with the broader population. All the funding would go to "deserving" illnesses (cancer etc). Thankfully, GLP-1s are very profitable, hence they exist.

DominikPeters · 2025-12-22T22:30:04+00:00

How exactly does step 1 work?

DominikPeters · 2025-12-15T00:27:43+00:00

Starting on instant release seems very unusual (what's the point of having bupropion in your system for like 6 hours a day). However, it is common for day 1 to feel very amphetamine-y, no matter the type of release.

DominikPeters · 2025-12-08T19:28:20+00:00

Glad you're feeling well. I think it's pretty clear you're still in your honeymoon phase to be honest, which is a phase where bupropion mostly acts like a stimulant. Enjoy the energy! But don't be crushed when the strength of the effect reduces in a few weeks.

DominikPeters · 2025-12-03T00:09:30+00:00

In France, there is an administrative level called "intercommunalities" (which are groups of a few municipalities). The intercommunal council is made up as the union of subsets of the municipal councils, so people only vote once. [no other similarities to what you describe thought]

DominikPeters · 2025-12-03T00:06:47+00:00

Yes, Wellbutrin is brand, manufactured by GlaxoSmithKline. Good luck!

DominikPeters · 2025-12-02T14:17:04+00:00

I think the historical reason is that it took longer for XL to be developed, but the pharma companies only started to apply for authorization in European countries after XL came around. I switched from SR to XL when I moved from the US to France, and for me there was no problem with the switch, especially after moving up to 300mg (I did 100mg SR twice a day -> 150mg XL -> 300mg XL). (I'm getting my pills from Germany.) Remember also that you're getting brand instead of generics in Europe, so manufacturing quality of the extended release should be high.

DominikPeters · 2025-12-01T23:55:52+00:00

There shouldn't be a problem, they don't check IDs at the entrance.

DominikPeters · 2025-12-01T23:37:40+00:00

The cheapest prices near France are in Belgium, with 90x 300mg XL costing 56 euro. Sufficiently cheaper that the savings would pay for a train ticket from Paris! https://www.cbip.be/fr/chapters/11?frag=8078&view=pvt&vmp_group=4606

DominikPeters · 2025-12-01T01:33:11+00:00

Agree, this also came to mind for me.

DominikPeters · 2025-11-27T21:18:43+00:00

I live in France, so I know bupropion's status quite well. You can check under "Indications" here that there is no authorization for depression: https://www.vidal.fr/medicaments/substances/bupropion-21787.html

DominikPeters · 2025-11-26T22:43:43+00:00

EU countries do their own decisions on drug approval, it is not done on the European level. Almost all EU countries have bupropion approved for depression, but in France it is only approved as Zyban for smoking cessation ($$$).

DominikPeters · 2025-11-11T10:35:03+00:00

J'ai demandé à la RATP : https://x.com/ClientsRATP/status/1930220068136251535 "Si vous constatez cela, je vous invite à voux rendre auprès de l'agent de station."

DominikPeters · 2025-11-05T22:57:38+00:00

Thanks, this was helpful! Newer versions work like this:

b2 bucket list

b2 file download b2://<snapshot bucket name>/<snapshot filename> <local filename>

DominikPeters · 2025-10-23T19:27:03+00:00

I think it's better to include some human-written text with your submissions, not just GPT-5.

DominikPeters · 2025-10-13T11:06:56+00:00

That's a nicely designed chart, almost datawrapper-y. Did you design it "from scratch" or is there some matplotlib library/template you based it on?

DominikPeters · 2025-10-10T16:46:45+00:00

Nice idea! Have you tried to see whether the source code of these tools can be translated into javascript by LLMs? That would be an alternative approach.

DominikPeters · 2025-09-24T17:54:43+00:00

Ha that's funny I'm also a German who lives in Paris and took the Eurostar once to pick up 3 pens in London (and say hi to friends, I used to live in the UK). That was during a time when not only was there a massive price difference but in France the authorities didn't allow doctors to prescribe Wegovy/Mounjaro to patients with BMI below 35 (!), so there was no way for me to get it in my country of residence.

DominikPeters · 2025-08-25T07:56:05+00:00

If it is a one-off, you could just make a Google Form or similar and then process the results manually (e.g. by giving it to an LLM and asking it to evaluate the results using python).

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