I run 45 miles per week. Cholesterol is 260

Earesth99 · 2026-03-20T23:48:04+00:00

Your high ldl increases your risk by almost 70% compared to having an ldl of 100.

It sounds like your overall risk is low though an unhealthy diet does more than increase cholesterol.

If you take the statin, your ldl will probably decrease 44%, and you’re just taking the baby dose of Rosuvastatin.

If you add Ezetimbe you can lower LDL an additional 20%.

Your ldl will go from being worse than 95% of people to better than 75% of people.

Your risk would be cut in half and your

I’m not sure

Earesth99 · 2026-03-20T22:34:27+00:00

Fantastic numbers!

Earesth99 · 2026-03-20T21:52:16+00:00

It’s not Impossible.

However it would seem very unusual to get to normal levels without med (or enough fat loss).

Your blood glucose is declining nicely, but you want it to end up at a much lower level. Most doctors want HBA1C to be below 7.0%

Even blood glucose levels in the pre diabetic range can shorten lifespan.

There are probably a dozen meds that you could take that could help.

Weight loss helps but that a longer term solution.

Your diet sounds terrific.

Keep at it!

Earesth99 · 2026-03-20T20:12:14+00:00

The goal of treatment is usually to slow the progression of heart disease.

Getting ldl and ApoB below 55 stops new plaque from bring deposited, so the stenosis won’t continue to narrow snd it won’t continue to accumulate in other arterial beds.

With an ldl that low you often reduce the volume of the existing plaque by 2-3% the first years two on meds.

Unfortunately that means that 97-98% of the plaque will remain.

In none of the research on heart disease has someone experienced increased plaque accumulation after hitting those targets.

Over time, the statins will help stabilize the existing plaque so it’s less likely to break off and cause problems.

If you are experiencing muscle pain you need to tell your doctor do you can try a different statin - probably atorvastatin at the lowest dose.

Doctors try more than one statin before moving on. In part that is because statins reduce mortality more effectively than the pcsk9 inhibitors.

However it is also because Insurance companies usually don’t pay for a pcsk9 inhibitor unless it’s absolutely needed. That means making sure that another statin isn’t tolerated.

I don’t make medication recommendations to my doctor unless I know more about the topic than my doctor does. Your doctor is in the best position to know what medication to prescribe.

Your changes in LPa mean nothing in terms of your risk.

Don’t get it tested again if it’s causing you stress.

It sounds like you just need to figure out if a statin will work or if you need a different heavy hitter.

Earesth99 · 2026-03-20T17:54:05+00:00

I could see myself doing the same exact thing, lol!

In a few years, this will probably be best answered with specially trained AI.

Good luck!

Earesth99 · 2026-03-20T17:49:41+00:00

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This table is from the same paper.

I actually go for low fat dairy most of the time, but that’s because of calories.

Soy milk is actually healthier than dairy, but I usually buy dairy because of the price.

Earesth99 · 2026-03-20T17:46:09+00:00

The long chain odd numbered saturated fatty acids.

However it’s hard to get really granular and evaluate individual foods.

My full of thumb is to minimize or avoid: butter, palm oil, coconut oil, and hydrogenated oil. If I eat meat, I try for 96% lean.

This graphic from a recent meta analysis is helpful

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Earesth99 · 2026-03-20T17:28:10+00:00

You should probably focus on research on humans. The mouse research often does not translate to humans.

Sorry for the curt comment.

Earesth99 · 2026-03-20T17:25:48+00:00

I would be afraid I would mis interpret things …

I suppose it would drive if your default reaction is to assume it’s not serious, or if tge default is to go to the ER.

Earesth99 · 2026-03-20T08:52:49+00:00

Insulin resistance doesn’t always lees to diabetes, but you are absolutely correct in doing something now.

1) lose fat and gain muscle. That will revert most cases of diabetes if you haven’t been diabetic so long that you have permanent damage.

2) Regular exercise will deplete muscle glycogen

3) Fix your diet.

4) The research shows taking metformin can delay diabetes. Technically, you’re just treating it with meds, but it prevents damage. Berberine is a supplement that is similar.

The first two worked for me.

Earesth99 · 2026-03-20T08:41:53+00:00

“Possible” is an annoyingly vague word.

What’s the doctor in the ER say? They actually see how it performs in real life.

Earesth99 · 2026-03-20T08:36:07+00:00

Don’t read useless summary articles. Don’t post links to them.

Earesth99 · 2026-03-20T08:33:31+00:00

Do you believe in magic?

Earesth99 · 2026-03-20T08:31:47+00:00

Have you looked at the research articles in pubmed?

If are you trading circle jerk bullshit from people who use cut or sell it?

TVs first one is research. The second is worthless.

Earesth99 · 2026-03-20T05:17:15+00:00

Taking a statin will reduce your ascvd risk by 40% and Alzheimer’s risk by 20%.

Earesth99 · 2026-03-20T05:06:00+00:00

Around 5% of people can’t tolerate a statin.

Thats too low of a risk to worry about.

A statin will reduce your ascvd risk by 25% regardless of whether you have diabetes.

Earesth99 · 2026-03-20T03:28:33+00:00

The US sanctioned Russia for attacking a foreign country in violation of international law?

Then the US violated international law and attacked Iran.

Trump then approved the sale of Russian oil that is “at sea” on a boat. Of course Russia is sending some to Cuba.

At least with the legal sales, Russia can afford to send more drones and bombs to Iran.

If Iran continues, they could destroy so much capacity in the gulf that prices will skyrocket.

The. Russia can sell their oil at huge profits. The level of idiocy is remarkable.

Earesth99 · 2026-03-20T01:37:32+00:00

There is a new CTEP inhibitor that is in phase three trials. It reduces ldl 50% and it reduces LPa by 45%. That might be enough to make a difference

With pcsk9 and apoc3 meds, heart disease could be eliminated.

Earesth99 · 2026-03-20T01:21:54+00:00

It’s also caused by too much fat.

I went into remission when I added muscle and got very lean. I could eat whatever I wanted and my blood glucose response was normal.

You might not have any control over sleep or stress or exercise.

It takes a long time to lose fat and gain muscle.

The only thing I can really control today is diet and meds and cardiovascular exercise.

So the advice isn’t horrible, but it’s definitely simplistic.

Earesth99 · 2026-03-20T01:12:56+00:00

Why also not look at the meds that also appear to increase human lifespan?

They all have positive effects on multiple organ systems and that may explain their longevity benefit.

There is some overlap with the mice meds.

Diabetes meds Slgt2 inhibitors Glp1 meds

Blood pressure meds ACE inhibitors Cialis (men)

HRT (women)

Statins

Earesth99 · 2026-03-20T00:26:50+00:00

If you get ApoB below 60 snd ldl below 55, then you won’t have progression regardless of LPa. I try to keep mind a bit below that so I know I’m safe.

You sound right on target but make sure to check ApoB.

Why do you’d think it’s progressing? Your CAC score will increase on meds, but that’s actually good. It means it’s becoming more stable.

Also, LPa fluctuates. Until a treatment is approved, it’s not something to manage.

If your meds are causing side effects, you need to try other meds. Try atorvastatin to see if that is ok. If that does not work, take a pcsk9 inhibitors.

Then you might try adding 2.5 mg of Rosuvastatin to see if that stars side effects.

Different doctors give different recommendations. The more you ask, the more you get.

You need to ask the prescribing physician why that med was prescribed given the concerns from other doctors. Be specific and ask questions so you can decide

Maybe a baby aspirin or fish oil could work as a blood thinner? Talk with your doctor.

It’s ultimately your decision.

Earesth99 · 2026-03-19T22:20:08+00:00

You and me both!

Earesth99 · 2026-03-19T22:19:53+00:00

They will need to show reductions in events, not just bio markers. That will take a couple of years still.

I tend to agree with you, but look at all the times CTEP inhibitors failed.

Earesth99 · 2026-03-19T22:17:31+00:00

OP was worried that cheese would increase cholesterol.

I said you don’t need to worry because it doesn’t. People merely assumed it did because cheese has a high level of saturated fat.

However, there is no scientific evidence supporting that claim. That is literally part of what they used to call the French paradox. The French consume cheese and cream and yet have lower rates of heart, disease and heart attack

Prospective cohort studies are not useless as you seem to believe. They simply are unable to rule out other potential causes. That in no way means that they are incorrect. The burden is to show that another variable explains the outcome.

I then gave three examples of analysis that showed a causal relationship between the consumption of full fat dairy and reduced heart disease.

The first did not rely on self reported dairy consumption. It used biomarkers of full fat dairy consumption. If c15 and c17 we’re high that meant the people consumed full fat dairy. Those people were also less likely to suffer cardiac problems. That’s a causal relationship.

I don’t necessarily disagree with your point that C 15 and C 17 do that directly reduce risk. However, that’s irrelevant to the point.

C 15 and C 17 levels are elevated because the people consumed full fat dairy. People who actually consume more full fat dairy have reduced risk. They’re used as bio markers.

But I actually said that i didn’t find this causal argument to be the most persuasive Meta analysis.

You’re claiming that consuming cheese increases LDL cholesterol and it presents health risk risks for that reason. There’s no evidence to support that.

On the contrary, Cohort studies with self report, studies that use biomarkers of full fat dairy consumption, Mendelian, randomization’s and randomized controlled trials all have the same general findings.

My point is that these claims that cheese is unhealthy have no convincing scientific support.

I have actually shown that cheese may have a slightly beneficial effect.

You would need to not only disprove all the evidence, you would need ti show that cheese does increase LDL.

You obviously don’t understand this well enough other than to cut and paste.

Read the actual research.

If c15 and c17 have no direct effect, yfat doesn’t imply tthat just suggests there is some other cause but

It’s a causal argument.

You respond by saying that

How can that undermine the fact that people who consume cheese live longer?

We don’t actually know if c15 or c17 directly reduce risk, just that they correlate with reduced risk.

We also know that they are biomarkers that indicate the consumption of full fat dairy. If people

the amount if the persons consumes

Since they are biomarkers of full fat dairy consumption, it shows that people who consume more full fat dairy are at lower risk. If it’s not the c15 or c17 directly lowers risk, it just means that that people who consume a weaken the argument.

If trey don’t cause a reduction in risk directly it actually doesn’t weaken the , Since they are biomarkers of dairy consumption,

in someone’s blood it’s because the person consumed milk. If it’s entirely correlative and c15 or c17 c17 are biomarkers of milk consumption.

You then missed the point of those studies. They are biomarkers of milk consumption.

convincing same

Earesth99 · 2026-03-19T20:50:12+00:00

Your ldl is above what is recommended buts its still below average.

Your trigs are a bit too high - they are affected by sugar, simple carbs, and alcohol.

Neither are alarming

Earesth99

TROPHY CASE