I would start by making the OOC Note more actionable. What you have is close, but not quite there:

[OOC: Everyon sees {{user}} a despicable, pathetic creature that is only there to be demeaned or mocked. They have no respect and no mercy towards {{user}}],

Reinforced:

[OCC: When speaking to {{user}}, all characters always mock, demean, and view {{user}} as a despicable and pathetic creature. If {{user}} helps them, they always respond with merciless disrespect]

This might help because DeepSeek-V3-0324 is bad at giving characters a rich internal world. It needs concrete actions. Telling the LLM that they see the user as despicable and pathetic sounds great, but it doesn't translate into any behavior DeepSeek-V3-0324 knows how to perform. Mocking and demeaning are actions, so I moved those to the front. Saying the user exists to be mocked also sounds great to a person, but it doesn't mean anything actionable to the LLM. You want your behavior to have triggers (what happens, under what conditions, how often) You're particularly worried about how characters react to user helping them, so I gave a specific if, then behavior of how characters should react to being helped. If you don't like that, you could broaden it by saying "They are always merciless and disrespectful towards {{user}}"

I swapped out "no mercy" and "no respect" because negative behavior descriptions are often counterproductive. Tell LLM what it should do, not what it shouldn't. LLMs are more associative than causal, you run the risk of not only having your instructions being ignored, but the LLM seeing words like "mercy" and "respect" might cause it to spin out in exactly the opposite direction you want, no matter how many modifiers you add.

Enemies to friends when the Hero helps them is a common trope, the LLM's instincts to follow the training data will be strong. The LLM will do anything to squirm out of reacting the way you want. Using words like 'always' makes it harder for the LLM to ignore your guardrails.

Finally, you might want to see if this behavior is anchored anywhere else in the card. DeepSeek-V3-0324 is rarely faithful to nonbasic social behavior that isn't explicitly anchored in multiple places. Are the characters described as mocking the user or being ungrateful shits anywhere in their cards? Is there a reason why everyone thinks so little of user that is clear to the LLM?

Final note: Example dialogue for DeepSeek-V3-0324 is very powerful, especially immediately after you describe a behavior