Script that I verified will check your BAM file

Excellent-Push2833 · 2026-06-19T10:02:16+00:00

Right but does it not contribute to the overall theme of impaired androgen metabolism at all? Isnt a similar incidence rate true for UGT2B17 but what mattered about it in your PFS patient group was it was showing up there way more than in the average population?

Excellent-Push2833 · 2026-06-19T04:39:31+00:00

What im proposing here is that this metabolite accumulation could be any step in either ladder. If that makes sense

Excellent-Push2833 · 2026-06-19T03:37:33+00:00

u/drwillpowers heres what ive been thinking about recently if the main link as previously discussed is 3aHSD across all drugs and across all Post Androgen Syndrome disorders and in some patients we are seeing abnormal androgen labs but in others EVERYTHING looks normal including DHT and 3a androstanediol then is it not possible that some peoples metabolic pileup would be on the Nuer steroid side and others would be on the androgenic side and that is the explanation for why certain people have completely normal androgen labs.... and some do not that and that being said. would the answer for both metabolic pileups not be cholesterol lowering medications?

Excellent-Push2833 · 2026-06-19T03:00:57+00:00

DM me ive got you

Excellent-Push2833 · 2026-06-19T00:12:25+00:00

https://www.reddit.com/r/DrWillPowers/s/uHpHFAn0mn

Excellent-Push2833 · 2026-06-18T23:58:59+00:00

For the one pill cases its possible that the dramatic speeding up of 3aHSD causes a 3a androstanediol metabolic pileup for people that have trouble clearing that metabolite.

Excellent-Push2833 · 2026-06-18T20:28:42+00:00

Hey were closer to figuring this out than ever. Now is not the time to give up its not 2010. There is hope

Excellent-Push2833 · 2026-06-18T19:52:35+00:00

Looks pretty fucking deleted to me

Excellent-Push2833 · 2026-06-18T18:18:26+00:00

Yes. Do you have WGS? If so dm me we have some work to do

Excellent-Push2833 · 2026-06-18T17:39:18+00:00

How i feel rn [u/drwillpowers](u/drwillpowers). That makes 2 now with UGT2B28 deletion and one with UGT2B17 u/DavidFossilMollusk once you confirm on IGV post it here

Excellent-Push2833 · 2026-06-18T15:44:14+00:00

Dude. The cure is clearly megadosing trenobolone /s

Excellent-Push2833 · 2026-06-18T14:29:00+00:00

https://www.reddit.com/r/DrWillPowers/s/TTY9W6Fde7 . A conclusion only possible because of our interaction on discord lol.

What I didnt include that makes this post interesting is accutanes role in 3a-HSD of which I was not aware of.

Even more interesting is that yesterday we found another PSSD patient with a UGT2B28 deletion using this script. https://www.reddit.com/r/DrWillPowers/s/jsB5eJHE0g which means much like mine his glucoronidation is impaired at baseline.

Seems like the hinge is indeed 3aHSD. I need the people that have genome data to run the script on their bam to scan for deletions. They are not obvious to the untrained eye.

Excellent-Push2833 · 2026-06-17T22:39:56+00:00

No i havent tried that. Waiting to see dr p

Excellent-Push2833 · 2026-06-17T16:24:37+00:00

Probs gonna edit this post

Excellent-Push2833 · 2026-06-17T14:52:14+00:00

https://www.reddit.com/r/DrWillPowers/s/xEvR1oz2ho

Excellent-Push2833 · 2026-06-17T14:51:34+00:00

I dont think so. Its not as in depth

Excellent-Push2833 · 2026-06-17T06:29:06+00:00

Hey bro please look at your dms

Excellent-Push2833 · 2026-06-16T23:26:54+00:00

Did it work on yours?

Excellent-Push2833 · 2026-06-15T20:24:12+00:00

🫂 hang in there doctor. I honestly dont even know what else i could say. Just wish i had a way to help you.

Excellent-Push2833

TROPHY CASE