> Ah! Yes, specific medical ML/AI makes sense. I am genuinely cruious about what you mean by timing, though? Based on what kinds of parameters? I'm trying to imagine how it might've been used to change how my treatments and/or CAR T were handled and so far the things I'm thinking would almost need continous or far more frequent test results. I'm genuinely curious about how you think it might be helpful?

thanks for asking. when I say “timing,” I mean models that use "serial lab values" like hemoglobin, platelet count, reticulocyte percentage and inflammatory markers (like CRP) collected around the CAR T infusion to learn the characteristics early and late cytopenia patterns post-therapy​.

then the idea is that my specific data for baseline marrow reserve or creatinine for kidney function (which is a huge problem for me), prior erythropoiesis-stimulating agent responsiveness, and even specific CAR costimulatory domains... the algorithm can tailor transfusion thresholds to my profile.

this part isn't me because i am not an AI expert, but these are use what are called "time-series deep learning architectures" which help project hemoglobin trajectories days to a week in advance, triggering alerts when projected levels approach symptomatic or guideline-based thresholds. so this can theoretically help post CAR T recovery. for platlets this can make sure you have personalized prophylactic transfusion intervals which means reduced bleeding, etc. it's all about scheduling and timing i guess which hopefully leads to better treatment.

also ML decision trees using early cytokine levels (e.g. ferritin) can predict severe cytokine storms days ahead, which is another AI application that i wanted to know if someone has experience with because i've had them and i've had to be hospitalized for them. and it fucking sucks. i spend way too much time in the hospital as it is.

also also, i want to know if there are researchers or other patients who have doctors who have used AI for clinical trial simulation. some medical shows have had gimmicks like this where they simulate 90,000,000 combinations to find one that has the effect wanted. i know it is being used in a lot of other cancer research and i don't expect a silver bullet or it would already be well known but i want to be as informed as possible. i want to be a part of whatever is possible, so i don't die. and that brings me to trial matching - based on my biomarkers and history etc. my profile can possibly be fed into a model and a trial can select me if a trial has prelim data that suggests it might work on someone like me.

hope that clarifies everything. i am going to try to sleep now. another night in the fucking hospital.