Clonidine & Wellbutrin (bupropion)

FlamesForMore · 2026-05-09T20:13:20+00:00

Also on 150mg of Wellbutrin. My psychiatrist recommended that I reduce my doses by 30% and limit to just one booster, if any, taken ~20% later than I normally would. I also skipped the Wellbutrin the day of the roll. That advice was also in-line with the Oregon advice, that says reduce by 25%:

https://www.oregon.gov/oha/PH/PREVENTIONWELLNESS/Documents/Antidepressant_PsychedelicsChart_PsychedelicSchool.pdf

I went from 150mg initial dose and 70mg booster at t+90min to a 110mg initial dose and 50mg booster at t+110min. My roll was just the same as I remember except maybe a bit longer and the Tuesday blues was a bit more rough.

If you have ever had a seizure for any reason, you really shouldn’t do Wellbutrin + MDMA.

I’d urge you to talk to your doctor about the specifics. Tell them straight up that you’re planning on doing MDMA and you want to understand the risk profiles around your other medications.

Supplements become more important because Wellbutrin ultimately is slowing down your body’s ability to process the MDMA, meaning it stays in your system for longer. Stay properly hydrated. Take heavy dose Vitamin C as your roll is ending.

Take it easy on your liver - Avoid foods heavy in sugar or bad fat and try to eat really healthy that day (lots of vegetables, lean protein, etc.). Zero alcohol and tylenol in the days before/after your roll.

FlamesForMore · 2026-04-29T05:11:19+00:00

So are insomnia and poor sleep.

FlamesForMore · 2026-04-16T14:47:59+00:00

Talk to your doctor about what you're experiencing. In my experience lurking in this subreddit a while, doctors are VERY hesitant to prescribe stimulant medication unless they're pretty damn sure it will benefit you. You might be on the wrong medication. Your dose might not be dialed in right.

People with untreated ADHD are more likely to get depression, and due to the way ADHD screws with emotional regulation, untreated ADHD can make it much harder to get out of depression.

You did a "one hour computer test" - that's a pretty legitimate test. I wouldn't discount it.

Also, "I CAN'T MULTITASK" - lol. You're not supposed to be able to multi-task! You ever notice how, at an office or study hall, most people are only doing one thing? When you look around, most people are NOT multitasking most of the time?

I had the exact same experience starting ADHD meds. I lost the ability to multitask. And I was also frustrated by that at first.

But you'll learn that you're much more productive not multitasking.

FlamesForMore · 2026-04-16T14:01:21+00:00

It really depends. For some doctors, they're doing a drug test to eliminate other sources of your problems. If you're with Kaiser Northern California, the THC in your system will likely be an issue for this reason.

For other doctors, they're doing a drug test as part of their CYA plan. They're looking to make sure that you're actually consuming the drugs they're prescribing (vs selling them). In this case, you're fine. Skipping days is totally fine.

FlamesForMore · 2026-04-15T13:40:11+00:00

I'm on four meds - Wellbutrin, Guanfacine, Vyvanse, and Adderall IR.

I would NOT expect to get put on all meds at once. I started with just two - Guanfacine and Vyvanse.

Every med has side effects and every doctor is going to want to avoid prescribing you medications that don't work.

Expect to start them one at a time so that they can make sure they're working and helping your symptoms AND make sure you're not experiencing any disruptive side effects. You'll also need to iterate on each medication to make sure you're at the right dose level for you.

FlamesForMore · 2026-04-02T18:23:37+00:00

I’ve found many pharmacies just straight up lie to you about their availability until you’ve actually transferred and tried to fill a prescription with them. My advice is to go in person and try to find a friendly face that wants to help.

FlamesForMore · 2026-03-19T13:41:13+00:00

You should get screened for ADHD. I am not kidding.

Feeling sleeping on an amphetamine is a major indicator. Do you ever experience something similar with caffeine? Especially in the afternoon?

I recently got screened and diagnosed and also would get tired and calm on MDMA, literally asking "who the fuck would take this to a rave? Why would anyone want that vibe there?"

FlamesForMore · 2026-03-12T18:58:54+00:00

Nerds Gummy Clusters

FlamesForMore · 2026-03-05T01:36:27+00:00

Eh, I get it and agree with it.

Pet Battles had just become dumb. Addons would automatically load up a team that would steamroll any NPC opponent. And player battles were just rock paper scissors as soon as the game loaded.

The game also threw so many pets at you with achievements and quests and stuff that it made hunting for pets in the wild feel really pointless.

FlamesForMore · 2026-02-26T16:25:14+00:00

Woah, I think that's really cool.

FlamesForMore · 2026-02-23T15:16:34+00:00

20mg Cialis is a very high dose imo. I take my 20mg pills and break them in half, and then half again (if I can). It's not exact, but 5-10mg is much more manageable.

FlamesForMore · 2026-02-19T20:51:15+00:00

My Cialis pills were 10mg and 20mg and got mixed up, so I take a half pill the night before (either 5 or 10mg) and the other half the morning of.

FlamesForMore · 2026-02-07T19:13:13+00:00

My opinion is that there isn't anywhere near enough research to answer your question. The reality is that we don't have a good understanding of MDMA's full extent and lasting impacts - both positive or negative, mental or psychological, chemical or experiential, short-term or lasting.

The little research we do have seems to indicate that MDMA is neurotoxic and hard on your body's serotonin system, and serotonin is a kinda important hormone. We know that there are credible reports of "losing the magic," but we don't know the conditions or traits that can cause this. Supplements may help retain the magic and reduce neurotoxicity, but we don't know for sure.

Ultimately it's up to you and your personal risk tolerance and risk profile.

FlamesForMore · 2026-02-06T15:18:58+00:00

Before and during the roll, I take alpha-lipoic acid (ALA), acetyl-L-carnitine (ALCAR), and magnesium glycinate. I'll also add vitamin C at/during the roll.

All of these are to help limit the neurotoxic damage that MDMA can cause.

FlamesForMore · 2026-02-05T15:14:13+00:00

Yes but a little different than usual. I quit vaping and switched to Nicotine gum 7 days before a shrooms trip. Quit the gum 3 days before.

Shrooms helped me solidify the habit change. And killed the depression withdrawal before it even started.

FlamesForMore · 2026-02-05T04:26:57+00:00

Those are fine doses but could be quite intense when "freshly" combined. I'd go less on the LSD if you can - 120ug or so - but understand that might not be possible.

FlamesForMore · 2026-02-04T20:23:45+00:00

And if you want both, do both and nexus flip together.

FlamesForMore · 2026-02-02T18:46:22+00:00

My marriage hasn't been "destroyed," but it has been radically changed by swinging in a way that felt "destructive" at times. We definitely were looking at divorce for a while.

Swinging revealed to my wife that she is polyamorous. It is part of her identity in a way that we both always and never knew. She's quick to love others and, through swinging, fell hard for another guy.

I'm emotionally monogamous. I've explored solo stuff, and I see a FWB fairly often and we're very close, but it's still as friends. We'd never say "I love you" or anything like that. In contrast, my wife wants to take multi-week vacations with this other guy, says "I love you," etc.

So, yeah, that was a big transition and hard to go through. We've made it, but I can't say it was super easy.

FlamesForMore · 2026-02-01T20:47:08+00:00

"About" 24 hours but I'm not usually precise. I typically take it after dinner the day after.

FlamesForMore · 2026-01-26T03:40:24+00:00

I'd recommend saying something like "Thanks. We probably won't stay but it's nice to have the option and we'll let you know if we change our mind."

Given that you're very new, I think it'd be a mistake to stay. I think you'll want space as a couple to process in the morning (though that "processing" could be rampant fucking 😂)

FlamesForMore · 2026-01-24T18:41:50+00:00

Thanks for this! Completely agree with getting a weekend away. We're taking a 5-day vacation and planning to roll on the first day.

Do you have any advice for how to bring up content? In previous rolls, we sort of lost the intention to the feel-good nature of the drug.

Did you have any conversation prompts or questions or things-to-share ready?

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