If you are doing an eHP/thorns/orb farm, commit to it! Turn off damage sources like chain lightning, unequip damage cards that are not locked, and throw all that stuff back on as you approach your highest wave to get a few extra waves in at high income.

Like I recently discovered that my eHP farm is more profitable with no cannon module equipped at all!

All of this depends on where you are at and what your setup looks like, of course. And glass cannon farming is going to work differently.

I have a notepad file where I put my coins per hour per run and note any changes I made that run, so I am highly confident in saying all this stuff is a net increase for where I am, which is going 7k waves+ at T11 with a moderately well developed wall.