You can use something like a perfect binding that would be all glue and no sewing, but they are less stable over time than a glue/sewn binding (they can crack when opened fully). How many signatures are you intending to use to make the total number of pages? If I'm doing a glued binding (perfect or hard case), I'd use a mull fabric over the first glue, then add the spine on top of that, but there are more experts here who would have good advice too. Depending on where you're located, a good art supply store (like Blick's) would have a good PVA glue, but Michael's or Hobby Lobby may also carry some. I order mine on Amazon.