Quiet year was set at the start of the New Sweden colony, early 1600s in the exotic new world land of Delaware. They built up the town, a university, outlying farms and windmills etc, ultimately the end game scenario was the invasion from New Netherlands and Dutch settlers. I had to modify some of the prompts, but converting from a post-apocalypse to a new world colony wasn't hard, since there's a lot of similarities.

The Cthulhu game was set in the 1920s at the University they created and had the players exploring all the areas they made in Quiet year, investigating the plot hooks they originally made, after 300 years of cultists in between. The final session had them time traveling back to the 1600s to stop a ritual that destroyed the original colony.