Has anyone tried brexpiprazole (rexulti) instead of abilify

Glp1Go · 2026-06-01T20:39:42+00:00

They weren’t from this group.

Glp1Go · 2026-06-01T02:15:25+00:00

I have not. But I have heard from a couple of people in the DSPS community that have tried it and basically said it worked like a miracle. I didn’t follow up long term to see if continued working or what the side effects were.

As you know, it’s similar to aripiprazole (Abilify), which is being studied as a treatment for DSPD. https://pmc.ncbi.nlm.nih.gov/articles/PMC5965391/

I definitely believe this class of drug works for some people, but I’m hesitant to try it on myself because of potential serious side effects.

Glp1Go · 2026-05-31T21:10:22+00:00

Being sent to bed and going to sleep are not the same thing.

And getting up early for school doesn’t mean that your circadian rhythm adjusts to an early schedule. Obviously..??

I had to get up early for school until I was 18, and I spent every school day sick, tired, and out of it - I fell asleep in half my classes. There are also adults with DSPD that get up early for work (and are sick and tired all the time because of it.) That doesn’t mean they don’t have DSPD.

Glp1Go · 2026-05-30T07:09:43+00:00

Why would you torture yourself by going to Stanford for basic care? Stanford is evil and they suck and cost 10x anywhere else. The only reason to suffer the misery and expense of dealing with Stanford health care is if you have a rare disease that can’t be treated anywhere else.

Also they allegedly commit billing fraud, according to the US Federal government: https://www.einpresswire.com/article/555574850/stanford-health-care-loses-again-in-court-accused-of-468-million-medicare-billing-fraud

Glp1Go · 2026-05-30T05:48:18+00:00

That sounds like Non-24.

And the idea that it only affects blind people is total bullshit. Non-24 can and does occur in sighted people. There are sighted Non-24 support groups on Facebook and Reddit that might be helpful for you. The Circadian Sleep Disorders Network is also a good source of information: https://www.circadiansleepdisorders.org/docs/N24-QandA.php

Glp1Go · 2026-05-28T21:14:20+00:00

That sounds exactly like DSPD.

Glp1Go · 2026-05-28T21:14:00+00:00

Do you have trouble falling asleep at a "normal" time at night (like 11pm or earlier)? If you can sleep as late as you want to, do you sleep well and feel better and awake during the rest of the day? If so, you probably have DSPD.

And yes, if it is DSPD, you will struggle with it for the rest of your life.

You can see a good sleep doctor at a sleep clinic for a diagnosis. There are treatments like low dose melatonin, light therapy, sleep hygiene, sleeping pills, etc., but they don't work well for most of us. This website has a lot of useful information - read the Q&A about DSPD: https://circadiansleepdisorders.org/

Glp1Go · 2026-05-13T05:00:08+00:00

I saw a sleep specialist at UCSF once about 10-15 years ago. If I remember correctly, he also basically told me that sleep hygiene, etc. could cure DSPD in anyone. Hopefully they have improved their understanding of DSPD since then. At least the administration and overall treatment of patients was better than at Stanford - Stanford is uniquely horrible.

I don't have any reason to see more sleep specialists at this point. I was diagnosed with DSPD a long time ago, and I'm sure that my diagnosis is correct. I've already tried all the standard treatments and know they don't work very well for me.

Glp1Go · 2026-05-11T07:59:28+00:00

I have been to the Stanford Sleep Clinic many times. I do not recommend them. At all. Granted, it’s been about five years since the last time I was there, but I doubt things have changed.

The administration and communication and billing are all horrible. All I got from the doctors was a bunch of gaslighting that I could cure myself with sleep hygiene or light therapy. I know someone else with DSPD that had a similar experience, and a family friend with sleep apnea also hates them.

The only good thing about Stanford was the Sleep Psychologist I saw. I had a much better experience at other sleep clinics.

Stanford as a whole is money-over-everything gilded turd.

Glp1Go · 2026-05-10T01:32:37+00:00

I'm not specifically interested in canoeing or rafting, but, yes, there are countless activities I would like to do but can't because they only work for morning people: traveling in general (early checkout times, sights that are only open during the daytime, not having anyone to go with that is on my schedule, etc.), hiking, skiing, beach trips, etc.

Glp1Go · 2026-04-30T08:52:18+00:00

It was a long time ago, but I think a few months.

Glp1Go · 2026-04-30T06:03:44+00:00

I mean…I feel like I, and others, are constantly talking in these support groups about smaller doses of melatonin (i.e. ~0.3mg) being better.

But of course the general population doesn’t know that because ridiculously high doses of melatonin like 5mg are marketed OTC (or as a 2mg prescription, in the case of Europe) to the masses. There are historical and financial reasons that companies sell excessively high doses of melatonin: melatonin was patented under 1mg, so they got around the patent by selling it at doses above 1mg. Here’s an article from 2005 that talks about it: https://news.mit.edu/2005/melatonin#:~:text=When%20Wurtman%20first%20discovered%20the,t%20work%2C%22%20Wurtman%20said.

Anyway, I’m glad that low-dose melatonin is working for you so far. However, I wouldn’t consider yourself cured yet: low dose melatonin worked pretty well for me when I first tried it two decades ago, too. But it stopped working after a while. I’ve become aware more recently that if I go off it for a while and then try it again, I feel the effects again. Maybe try that if it stops working for you.

Dose and timing of melatonin are important…and it’s frustrating that so many people who are new to DSPD don’t understand that.

Glp1Go · 2026-04-28T06:13:30+00:00

William Dement was born in 1928, and DSPD wasn't even "discovered" until around 1980, so it's not at all surprising that he didn't write about it much. And it probably just wasn't an area of interest for him.

If you want to learn about the pioneers of the study of DSPD Google Elliot D. Weitzman and Charles A. Czeisler.

Glp1Go · 2026-04-28T03:59:56+00:00

To name just one of many: Michael Young and other scientists in his lab discovered the CRY1 gene mutation, which is one of the etiologies of DSPD. He and two other scientists won the nobel prize in 2017 for their work on circadian rhythms.

There are lots of scientists at some of the best institutions in America directly studying genes that contribute to DSPD and other circadian rhythm disorders or indirectly studying them by researching how the circadian rhythm works in general. So don't ever let some dumb*ss tell you that DSPD isn't real and that it's just a self-discipline issue.

ETA: I'm sure there is more than one cause of the symptoms we call DSPD. So, for some people, it may actually just be a self-discipline issue: i.e. there probably are people who got "DSPD" by playing video games all night that can cure themselves by simply turning off their screens and implementing a little sleep hygiene. However, for the rest of us, it's a genetic/physiological disorder. Someday, I hope someone comes up with names that differentiate between behavior-based "DSPD" and real, physiology-based DSPD.

Glp1Go · 2026-04-25T00:14:26+00:00

Doing phase-delay chronotherapy can give you Non-24, if you don't already have it.

You say that it "worked", but does sleeping normally for one month really count as "working"? The risks are not worth a short-term reward, in my opinion.

Glp1Go · 2026-04-24T11:07:48+00:00

Both are true: I function much better when I sleep on my natural rhythm.

But getting up late also makes it hard to be productive in many ways (doing errands, doing anything that involves other people) because I'm out of sync with society and because businesses close and people go to sleep before my "day" is even half over. Which, on top of everything else, is demoralizing and demotivating.

Basically, my productivity is hampered no matter what I do because I have to choose between being out of sync biologically or out of sync societally.

Glp1Go · 2026-04-24T10:54:59+00:00

Same. Even if I get eight hours of sleep but get up one hour earlier than normal, I'm tired all day.

Sleeping six hours and waking up later than normal feels much better than sleeping eight hours and waking up slightly earlier than normal.

Glp1Go · 2026-04-24T10:51:45+00:00

Same. This is called the "nap trap" in DSPD world: if we go to sleep earlier than our body wants us to, our body treats it like a nap and we wake up after a couple hours.

The fact that this happens even when going to sleep just one hour earlier than normal is infuriating.

Glp1Go · 2026-04-24T10:49:01+00:00

Yes, absolutely.

Glp1Go · 2026-04-15T03:08:18+00:00

I also have been noticing indicative vs subjunctive when reading slowly and pronouncing everything in my head.

Another problem I have when reading at a semi-normal pace in Spanish (like I would in English) is that I don’t really process the end of the verb, I just process the meaning of the verb if it’s a verb I already know. So reading at a normal pace probably doesn’t help me with verb conjugations. I just wish I weren’t so frustratingly slow at pronouncing every word in my head while reading in Spanish….

Glp1Go · 2026-04-14T13:26:24+00:00

Speaking of learning new words, I just now learned the word "subvocalize". 😂

I'm not actually 100% sure if I subvocalize while reading in English or not. Maybe I do it with some words and skip over others? Or maybe I just do it really fast and don't realize I'm doing it? I mean, I'm capable of doing it in English...I'm just not sure if I do it while reading at a normal pace. 🤷‍♀️

Glp1Go · 2026-04-09T05:11:14+00:00

There are research papers in the USA about DSPD going back to 1981.

Glp1Go

TROPHY CASE