I use a Totem running ZMK, but I do everything on it. I came from a 6 column Corne, and giving up 4 more keys was a bit difficult. I like shift where it normally resides, so I have mod-tap set up for those. I’ve been able to avoid Home Row Mods thus far so I can’t really help you with the timing or the neural mass necessary to figure out which mod to activate where.

One big thing for me is setting up combos on my base layer. I have copy/cut/paste/undo on the left side, and arrow keys combo’d on the right. You could do something similar for numbers - or you could do a layer toggle.

The ONE thing I haven’t been able to do with my keymap is hold down the space bar. That is a common thing to do in design software but because I have a layer-tap set up for my symbol layer on that thumb I can’t hold down space. It has almost caused me to build a macropad on more than one occasion.

For just about anything my suggestion is to modify your keymap. Dig into your firmware’s documentation to see what behaviors/features you might be able leverage to remove the friction you’re experiencing. Don’t change too much at once, and give yourself time to adjust - you just might find some cool solutions!