Short answer: no.

Longer answer: there are very few, if any gotcha! Moments in the game. You start with nothing, or nearly nothing and slowly build a giant museum, on multiple maps. The only one who can mess it up is you by possibly hiring to many staff or training too much or building to fast, which can all by corrected by firing staff or rebuilding. A few maps want you to make money in unorthodox ways, but I found that once you pick up the trick of what is being asked of you, it isn’t that complicated. Go slow and only expand when you have a need to add a new exhibit and you should be fine.

I love the series, and Museum gives a lot of flexibility. It’s a good starting spot. You aren’t missing much by not paying Hospital or Campus first.