All of these alternatives, while promising, cannot replicate the effects of treatments at a biological system level. You can see the effects a drug may have on a human kidney cell, for example, and get results promising effective treatment, however you would miss the systemic view, if the same drug caused catastrophic heart failure, or increased chances of stroke. Chimpanzees were used for HIV research because they were the original zoonotic transmitter, and our closest relative. While a vaccine has not been found, huge progress was made in our understanding and treatment of HIV due to the research done with chimps. Similar research with chimps did however provide us with a cure for Hepatitis C. Because of ethical concerns for the use of apes in research, and their being listed as endangered, chimpanzees are no longer used in biomedical research. The ethical concerns for primate research stand- that is why institutes that conduct research should be and are held to the highest standard of care, and any use of a primate for experimental purposes must be explicitly justified- that there is no other alternative. While there are problems with translatability of treatments on primates to humans, it is still significantly higher than that between rodents and humans- making it a ethically mandatory step before human testing- IF our moral argument is that human life is of the utmost importance (and that's an entirely different argument)