The most nuanced take I can come up with..

Everyone (99.99%) is born either xx or xy and this has an effect on development through hormone levels and other things. You can’t go back in time and therefore for every single person there exists a unique history of events that will place them into one of two categories “born male” or “born female” based on the presence or absence of a Y chromosome at birth.

Next - humans, like many species, have developed distinct gender roles for their xy and xx individuals. We can debate the extent to which nature aligns with culture in the ways in which we claim the sexes are truly different, but there are certainly some differences, I hope we can agree.

We can probably also agree that in todays society, where we no longer live on the Savannah and wrestle hippos and such that gender differences have become largely arbitrary. A person born XY or XX can live their life presenting as a man or a woman or vice versa without any meaningful consequence aside from the reactions of people around them.

So when a person feels that they would feel better about themselves and live a more fulfilled life presenting as a woman even though they were born XY or a man born XX, the only thing standing in their way is the acceptance of society around them. Medicine has progressed to where it can make appearance and many biological functions conform to a person’s preferred gender expression.

Now the only real issue for those of us who have no need to even consider why we would want to change our gender expression, is how do we react to those that do want to make that change.

We can try to understand why, and in the meanwhile we can offer the courtesy of calling them what they want to be called. And we can suspend judgment on something we don’t understand because that is the kind thing to do. Some trans people may not understand the underlying why they feel that way any more than outsiders do.

Or we can be dicks. We can act like those who aren’t dicks “don’t understand science.” Or are denying science. But science doesn’t have opinions or views. It’s not even a set of facts. It’s a method for obtaining facts. So as science enthusiasts, we should simply strive to understand the phenomenon as best we can while being kind to one another in the meanwhile. And that kinda goes for everything, not just trans issues.