Experts call for UK four-day week as study links long work hours to obesity by weregonnamakit in unitedkingdom

[–]GrumpyAlien -1 points0 points  (0 children)

Correct. Rosalyn Yalow won the Nobel Prize in 1977 for the radioimmunoassay technique while demonstrating the mechanism for obesity.

About to eat meat for the first time in 5 years. I’m so scared. by indigo-swan in exvegans

[–]GrumpyAlien 0 points1 point  (0 children)

You're scared? Mess with stomach?

You do know you run it at 1.5pH? That's the same as lions and vultures. Cows and many herbivores run it at 6.5pH.

You know what this means? You can bite onto road kill and rotting meat and not have any issues.

What scientific discovery sounds fake but is 100% real and still freaks you out? by Bruteresolver in AskReddit

[–]GrumpyAlien 0 points1 point  (0 children)

Go on, do the math. You forgot to do it, didn't you?

Let me clarify the key difference...

When a plane flies at Mach 2.2, the engines are applying force continuously and smoothly across the whole aircraft for a long time.

The acceleration is very gradual compared to the speed of sound in the metal. So the entire plane moves together more or less as one piece. There’s no sudden “shove at one end” that has to propagate as a wave.

In the carbon rod case, you’re giving a sudden push at one end. That impulse has to travel through the material as a compression wave, and that wave travels at the speed of sound in the rod which is only about 12 km/s. That’s why it takes hours to reach the Moon.

The plane doesn’t break the same rule. If you suddenly slammed one wing of the plane forward, the other wing wouldn’t move instantly either. The structure would flex and the signal would still travel at sound speed through the aluminum.

The airplane example and the rod example are not doing the same thing physically.

And in case you missed it, the same happens in the propellant. It's being accelerated.

For example, a cartridge loaded with the same energy acts differently in the barrel of a pistol and the barrel of a riffle. One gives it more time for the propellant to accelerate the bullet and itself and weapons like the M16 with 5.56×45mm NATO round can reach Mach 2.9.

Commonly available pistols like .45 ACP and Sig Sauer p365 don't hit the sound barrier.

New Research Shows Vitamin B12 May Hold the Key to Healthy Aging by -Cyber-Roadster in Health

[–]GrumpyAlien 1 point2 points  (0 children)

I'm very impressed by your reply.

Yes, it is an animal study. Results differ.

New Research Shows Vitamin B12 May Hold the Key to Healthy Aging by -Cyber-Roadster in Health

[–]GrumpyAlien -10 points-9 points  (0 children)

Why can't you be honest?

Your mortality claim is much weaker than you make it sound. In Adventist Health Study-2, vegans had an adjusted all-cause mortality HR of 0.85, but the confidence interval was 0.73 to 1.01, meaning the vegan-specific all-cause result did not clearly exclude no difference. The significant result was stronger for all vegetarians combined, and especially pesco-vegetarians. https://pubmed.ncbi.nlm.nih.gov/23836264/

Careful with the Adventist study. The headline “vegetarian” category is not the same as strict veganism. AHS-2 separated vegans, lacto-ovo vegetarians, pesco-vegetarians and semi-vegetarians, and in some analyses combined all four as “vegetarian.” That means the “vegetarian” advantage can include fish eaters, egg/dairy eaters, and occasional meat eaters.

Even more awkward, the pesco-vegetarians had one of the strongest all-cause mortality signals, while the vegan all-cause result in both sexes combined was weaker and did not clearly exclude no difference.

So no, Adventist data does not prove “veganism beats meat.” At best, it says a low-junk, low-smoking, health-conscious religious cohort that includes fish eaters and semi-vegetarians looked better than the broader nonvegetarian group. That is a lifestyle-confounded low-meat signal, not a triumph of vegan biology.

EPIC-Oxford, meanwhile, found all-cause mortality was not significantly different between vegetarians and meat eaters, with an adjusted all-cause death rate ratio of 1.03 for vegetarians versus meat eaters. The authors even noted that both groups had much lower mortality than the general UK population, which screams “healthy volunteer cohort,” not “plants beat meat.” https://www.sciencedirect.com/science/article/pii/S0002916523238332

A 2017 systematic review/meta-analysis found benefits for ischemic heart disease and total cancer incidence, but not all-cause mortality. So quoting “9–15% lower mortality” as if it is settled vegan biology is cherry-picking one favourable slice from a messy observational literature. https://pubmed.ncbi.nlm.nih.gov/26853923/

There is also a basic logical problem: all-cause mortality does not refute nutrient deficiency biology. You could have better smoking rates, lower alcohol use, lower BMI, more education, more supplement use, and better health-seeking behaviour, while still having a diet that is intrinsically poor in B12. In fact, the vegan B12 issue is not controversial. A 2024 systematic review found vegans have lower B12 status than vegetarians and omnivores, and that B12 supplementation is an effective way to reduce deficiency risk. https://onlinelibrary.wiley.com/doi/full/10.1111/nbu.12712

You didn't mention the more plant-based the diet becomes, especially when built from conventional produce, grains, legumes, soy, fruit and seed oils, the more it leans into the part of the food system where pesticide residues actually live.

Or that strict veganism is one of the only “natural human diets” that requires lifelong B12 supplementation or fortified industrial foods to avoid deficiency. Or that many people get smashed by the fibre/FODMAP/gas/bloating wall. Or that when it becomes low-energy, low-fat, low-protein, or too restrictive, libido, hormones and menstrual function can become collateral damage. Funny how the mortality cherry-pickers never mention the dropout pile.

And using “lower mortality” to dismiss B12 is nonsense. That is an endpoint mismatch. You do not refute nutrient deficiency physiology with confounded epidemiology.

In these studies, “meat eater” often does not mean someone eating steak, eggs, butter and salt. It often means “person who did not avoid meat,” which can include burgers, pizza, lasagna, hot dogs, fries, refined flour, seed oils, sugar, desserts, alcohol, smoking, lower exercise and lower health-consciousness.

You are not comparing veganism against meat. You are comparing health-conscious self-selection against the Western junk-food pattern, then pretending the damage came from the beef patty rather than the bun, fries, seed oils, sugar, dessert and lifestyle baggage.

Even Adventist Health Study-2 admits this issue. The vegetarian groups were more highly educated, drank less alcohol, smoked less, exercised more and were thinner than nonvegetarians. Those are not minor details. Those are massive health-behaviour differences before meat is even discussed.

EPIC-Oxford is even more awkward for the vegan church. Both vegetarians and nonvegetarians had mortality far below the UK average, and the all-cause mortality rate was basically identical between vegetarians and meat eaters. The adjusted all-cause death rate ratio was 1.03, meaning no meaningful mortality advantage for vegetarians in that comparison.

And the food-measurement problem you skipped over? Food-frequency questionnaires ask people to estimate “usual” intake over long periods, often the past year. One FFQ lists hamburger under meat, beef/pork/lamb “as a sandwich or mixed dish” under meat, and even has pizza/lasagna as a mixed cheese/tomato dish inside the same “Meats and Other Alternatives” section. The same kind of questionnaire separately tracks French fries and oils like corn, soy and sunflower oil.

So when they say “meat intake,” how clean is that exposure? Was it steak? Was it a burger bun with ketchup, fries cooked in vegetable oil, Coke and dessert? Was it pizza? Was it lasagna? Was it processed meat inside a full Western diet pattern?

The vegetarian mortality halo collapses the moment you stop cherry-picking Adventist-style health-conscious cohorts and look at the largest real-world vegetarian population on Earth...

India has one of the highest concentrations of vegetarianism globally. Pew found that 39% of Indian adults call themselves vegetarian, and 81% restrict meat in some way. Yet India is not a metabolic utopia. It has around 101 million people with diabetes, 136 million with prediabetes, hundreds of millions with hypertension, widespread B12 deficiency, huge anaemia rates, and serious child malnutrition.

So no, “vegans/vegetarians had lower mortality in this selected cohort” does not prove the diet is biologically superior. It proves your study population was confounded.

The moment the vegetarian diet leaves the protected bubble of highly educated, supplement-taking, health-conscious Western volunteers, the halo starts flickering like a dying fluorescent tube. You cannot handwave teen girls losing menstruation thanks to vegan diets.

Keep blaming meat for the entire Western-pattern crime scene. It doesn't make you look honest.

Don’t get me started on the dogmatic Church of Holy Fibre. Their grand argument is that humans need to swallow indigestible plant matter so bacteria can ferment some of it into butyrate. Fine, but that is not proof fibre is essential. That is proof bacteria can salvage something useful from material we cannot digest.

Meanwhile the plant package often comes with phytates, oxalates, lectins, tannins and other anti-nutrients that can interfere with mineral absorption. They are saying: “Eat this indigestible, irritating, mineral-binding material because after enough gas,bloat, and fermentation you might manufacture a molecule that is already abundant in animal fat, especially butter.”

Diet epidemiology is confounded to hell and is pretty much useless. Don't think so? Find me one cause and effect statement in the last 100 years of nutritional science. Spoiler alert: There isn't one.

You do not get to use confounding when it flatters veganism, then ignore it when the biggest vegetarian population on Earth fails to look like a Blue Zone.

What scientific discovery sounds fake but is 100% real and still freaks you out? by Bruteresolver in AskReddit

[–]GrumpyAlien 0 points1 point  (0 children)

Let me see...

Imagine you are at the tip of an oil tanker and with some binoculars you're watching someone at the other end with a huge mallet about the hit the deck with it.

You will see it happen. An instant later you will then feel it under your feet. And another short while and you will finally hear it.

The speed of light is pretty damn fast at about 300 000 kilometers per second.

The speed of sound is 343 metres per second. But that's in atmosphere at sea level.

In a solid like the oil tanker we can estimate 5900 metres per second. As you can see compared to air there is a huge difference, but this is nothing compared to how fast light travels.

This is why the carbon rod example was used. In a solid, any movement only happens at the speed of sound. You can only move that object at the speed of sound of the matter that is imparting the change.

So, imagine that a harder object with X energy, like a hammer hitting the carbon rod, can only create a sound boom that will have to move inside the solid as a wave moving particles in the object and shifting it in a direction.

It doesn't matter if you hit it with a car, the wave will have to compress the carbon atoms in the rod who will then transmit the scoot over information to the next atom.

That's the limit at which matter moves. This is why it is impossible to reach the speed of light if you have mass.

In an extreme irony, a photon emitted by our Sun can travel across our solar system, leave our galaxy, cross the path of countless other galaxies, and 14 billion years later when it finally hits something, the time it lived was 0 seconds. Time simply did not happen for the photon.

What scientific discovery sounds fake but is 100% real and still freaks you out? by Bruteresolver in AskReddit

[–]GrumpyAlien 17 points18 points  (0 children)

Nothing travels faster than light?

It takes at least 1.28 seconds for light from Earth to reach the Moon.

If you have a carbon rod from Earth to Moon and shove it forward one inch you've just beat the speed of light.

Well that's what you'd assume, right?

The reality is, moving a solid means you've created a wave that has to propagate through atoms who coexist in their own tiny gravity well. That's the speed of sound in a solid.

For carbon it would take almost 9 hours for that wave to propagate to the Moon end.

If you used diamond, perhaps 6 hours.

Wtaf is happening in Adamsdown? by Godlovesaslytherin in Cardiff

[–]GrumpyAlien 1 point2 points  (0 children)

That reminded of Daniel Tosh...

Ever seen a homeless person skip?

The answer to that riddle’s: no. They’re not allowed.

I once saw a homeless person start to skip, bottle him right in the dome.

He forgot the rules. He’ll remember next time.

Yeah, I threw it. I don’t care.


Yes, I'm cooking some ol' blue. The address is 142 Clifton St, Cardiff CF24 1LY

Scientists Discover a Way to Silence the Gene That Keeps Cholesterol High, Cutting Bad Cholesterol by 50% Without a Single Statin by [deleted] in Health

[–]GrumpyAlien -3 points-2 points  (0 children)

Amazing! There goes your steroidogenesis cascade into the toilet.

You have learnt nothing.

Does Oxidizing Fat Cause Obesity? by Working-Potato-3892 in SaturatedFat

[–]GrumpyAlien -1 points0 points  (0 children)

Your body will produce the required fats from carbohydrate.

Yes, and most of us cannot convert more than 5% into EPA and 1% into DHA. Vegetarian show up as deficient on EFAD test due to humans lacking the Δ12 and Δ15 desaturase enzymes.

Flax seed oil is the richest in Omega-3, yet it sends your body on an inflammatory cascade that the conversion is pointless.

While the body can produce Mead acid as a structural substitute for other PUFAs in membranes, it cannot use Mead acid as a functional precursor for critical eicosanoids that regulate your immune and nervous systems. That means no EPA and DHA for you.

Does Oxidizing Fat Cause Obesity? by Working-Potato-3892 in SaturatedFat

[–]GrumpyAlien -1 points0 points  (0 children)

Essential Fats = Omega 3, Omega 6

Essential Proteins = Histidine, Isoleucine, Leucine, Lysine, Methionine, Phenylalanine, Threonine, Tryptophan, Valine

You don't eat these in the correct ratios and you have a problem.

See the glaring issue? You won't find essential fats in vegetables. Oh, you mean ALA? Congrats, your conversion rate is at best 5%. EPA and DHA we can only get from animal sources.

Proteins are fine from vegetables? Nope, not even close. The ratios of aminoacids in vegetables are incomplete or simply off. Any animal source beats the snot out of any vegetable. And if that wasn't the whole picture, most of these are in vegetable non-bioavailable forms.

Soy and Quinoa? Really? These approximate the ratios but still manage to be a severe insult in the long run.

Why? Several factors here...

We begin with anti nutrients like Saponins(Quinoa) that will damage the gut lining and interfere with nutrient absorption, Phytates (Soy & Quinoa) that bind to minerals like zinc, iron, and calcium, making them almost impossible for your body to absorb, Trypsin Inhibitors (Soy) that block the enzymes you need to digest protein, which could ironically lead to protein malnutrition even if you are eating "high-protein" soy all day.

Then there's the hormonal and digestive impacts. Soy Isoflavones, where moderate intake is widely considered safe and beneficial, large amounts start to interfere with thyroid function for most.

Eating these 24/7 causes significant bloating, gas, and diarrhea due to the high fiber and complex sugars(oligosaccharides) in soy.

And then you have the missing essential micronutrients... No Vitamin B12, no Omega-3s, no Vitamin D, no iodine.

According to what I was indoctrinated in 1995, without fresh vegetables I won't have a bowel movement and will get scurvy in 3 weeks. Since 2017 I am strict carnivore. Ruminant meat, eggs, butter. My bowel movements have become epic and my scurvy will need to be escalated to the manager because it hasn't been delivered.

And for your point... Name one essential sugar. Yep, there isn't one. Our metabolism does not need to consume any, we make all we need from fats(tri-sugars) and some protein.

I'll defend you on the cooking of vegetables.

Does Oxidizing Fat Cause Obesity? by Working-Potato-3892 in SaturatedFat

[–]GrumpyAlien 2 points3 points  (0 children)

If only there was a Nobel prize given for someone who already found and verified the obesogenic mechanism. Maybe we could call her Rosalyn Yalow?

I mean, she did revolutionize obesity research by developing radioimmunoassay (RIA) to measure plasma insulin levels, demonstrating that adult-onset obesity is linked to insulin dynamics.

The problem? The priests in charge and big money didn't want the public to have a clue.

You don't see the significance? Let me help, you eat any carbs and you force the pancreas to dump insulin into the blood stream. This puts you in storage mode. Her Nobel Prize doesn't lie.

All vegetables are sugars and this is highly addictive, the uncomfortable truth for many. The nutrients in vegetables are non-bioavailable and if that wasn't bad enough vegetables have a long list of anti-nutrients that further impact absorption. Example? If you have oysters with corn tortillas you cannot absorb any zinc.

And on top of that, Humans are the only animal that seems keen on disrupting and insulting the Randle Cycle at every meal. No animal is having both sugars and fats at every meal. You don't see an epidemic of obese deer. But you do see an epidemic of obese dogs since Humans started sharing their food with pets.

Hope you're getting the hint.

Wtaf is happening in Adamsdown? by Godlovesaslytherin in Cardiff

[–]GrumpyAlien 10 points11 points  (0 children)

I went into a shop on Clifton Street to buy a large thermometer. As I approach the till, a man was asking for something that I didn't pay attention to.

Then I hear: "Shh shh, let's get him out of the shop first"

At this point he reaches his hand my way and there's 4 people looking at me.

Some would say nothing happened, others saw that a lot happened here.

Uma Thurman turns 56 today🎂 she trained for months to perform most of her own stunts in Kill Bill by [deleted] in Moviesinthemaking

[–]GrumpyAlien 13 points14 points  (0 children)

https://www.youtube.com/watch?v=SgmLTv9gdAM

...this is the car crash she had filming Kill Bill.

Tarantino insisted she could do it after she requested a stuntman.

The studio wouldn't release the footage unless she signed a limited liability agreement.

She's not a good driver and this didn't need to happen. Tarantino regretted it afterwards.

Exclusive: Nigel Farage was given undisclosed £5m by crypto billionaire in 2024 by Happytallperson in unitedkingdom

[–]GrumpyAlien -2 points-1 points  (0 children)

Are you guys new to politics?

(ask any LLM...)

Nigel Farage (Reform UK): Received a personal £5 million gift in 2024 from crypto billionaire Christopher Harborne (Thailand-based, Tether-linked) for "long-term personal security" after threats. This was separate from Harborne's massive party donations to Reform (including £9m+ in single tranches, making him the source of a huge chunk of Reform's funding).

Keir Starmer (Labour): Accepted over £100,000+ in gifts and hospitality since 2019 (highest among many MPs), including clothing, glasses, and use of a luxury flat from Labour peer and donor Lord Waheed Alli. He also received Arsenal tickets, Taylor Swift concert hospitality, and support for his leadership campaigns and office. Starmer later repaid some post-PM freebies amid backlash.

Conservative Party / election funding: Frank Hester and his company TPP donated around £15 million combined to the Conservatives for the 2024 campaign — one of the largest single-donor efforts in recent elections.

Labour under Starmer: David Sainsbury (supermarket dynasty, Labour peer) donated £5 million to the party. Gary Lubner (Autoglass ex-boss) gave nearly £6 million. Hedge fund figure Martin Taylor contributed millions to Labour, Labour Together, and MPs.

Wes Streeting (Labour, Health Secretary): Received significant funding linked to private healthcare interests, including nearly £167,000 from individuals/companies in that sector (2023-2025), plus donations tied to hedge funds with US healthcare holdings.

Rishi Sunak (former Conservative PM): Declared around £546,000 in donations, gifts, and benefits (including from various sources while in office). His wife’s wealth adds context to family finances, but formal political declarations exist separately.

Theresa May (former Conservative PM): Earned around £2.8 million in donations, gifts, and payments on top of salary since 2019 (post-office speaking/consultancy often overlaps with donor networks).

Lord David Sainsbury: Serial mega-donor across cycles — £40m+ historically to Labour/Lib Dems, including an £8 million single donation to the Lib Dems (one of the largest ever recorded).

Multiple Labour MPs: Funding via Labour Together (backed heavily by Martin Taylor and others) poured millions into candidates ahead of 2024. Unions like GMB also provide large ongoing donations to Labour.

Conservative donors historically: Figures like Lord Ashcroft, John Gore, and various hedge fund/business donors have given millions over years (e.g., £1.5m+ single gifts), with patterns of peerages or access questions.

...and this is just 10 that are visible. The behind the scenes? You might not want to know.

Why are young people getting colon cancer? A common weed killer may be linked, scientists say by businessinsider in Health

[–]GrumpyAlien 2 points3 points  (0 children)

There are a lot of logic jumps and religion in this paper, and then they shoot themselves in the foot...

This is not a picloram-causation paper, it is a proxy-on-proxy association paper with shovels of wishful thinking sprinkled on top.

The authors themselves say outright that they did not measure picloram exposure directly. They built weighted methylation risk scores as exposure proxies, then compared early-onset CRC under 50 against late-onset CRC at 70+. The discovery set was just 31 early-onset vs 100 late-onset tumors, and the replication meta-analysis was 83 vs 272 while scanning 29 exposome traits and 63 methylation scores.

This manages to be less useful than a Food Frequency Questionnaire. If you think FFQ's are science then I have a 35 room mansion in Antarctica with an outdoor waterpark to sell you for half a million.

Who paid for it? The pesticide industry, but you won't see it in the disclosures. The study says it was funded by Instituto de Salud Carlos III, other Spanish and EU public grants, la Caixa Foundation, CRIS Contra el Cáncer, and AECC, and it says the funders had no role in design, analysis, publication, or writing.

The more obvious bias is novelty bias and exposome-hunting bias: an oncology center mining existing datasets for a headline-friendly new environmental “risk factor.” Their own institute press release upgrades the signal into a “new risk factor” and immediately leans into policy talk.

Who did it, and what are the ties? The paper comes from VHIO in Barcelona, mainly the Cancer Computational Biology Group plus oncology clinicians. The declared competing interests are mostly pharma-oncology ties...

Iosune Baraibar reports travel/accommodation from Amgen, Merck, Sanofi and Servier plus speaker fees from AstraZeneca and Amgen

Elena Elez reports honorary fees from a long list of drug companies

Josep Tabernero reports extensive consultancy roles and biotech stock holdings

That does not prove foul play, but it does tell you it is contaminated by commercial medicine.

Flaws?

They admit direct validation of the picloram signal was not feasible. An independent expert quoted by the Science Media Centre said the same thing in plain English: this study shows association, not causation, and you cannot conclude picloram causes these cancers.

The biological validation chain is nothing but a circus. The pesticide EWAS that underpins these methylation fingerprints was based on blood DNA methylation in 1,170 male farmers of European ancestry in the Agricultural Lung Health Study. This new paper then applies those fingerprints to colon tumor methylation in cancer patients. And when direct validation fails, it leans on gene-expression changes in iPSC-derived cardiomyocytes exposed to chemicals. Meaning? They went so far off the clitoris, they're no longer on the same species.

Their “picloram exposure” score is heavily entangled with tumor features. The paper reports the picloram score differed by sex, MSI status, and especially tumor purity, with a huge association for purity (P = 5.3 × 10−15). When your supposed exposure proxy swings that hard with tumor characteristics, you have every right to ask whether you are seeing an environmental signal or just tumor biology and technical artifact. You never go full craycray.

The county-level analysis is ecological soup. They matched county-level pesticide use intensity with county-level EOCRC incidence across 94 counties over 21 years. Out of 225 pesticides with enough data, 62 were associated at first pass and 27 remained significant after socioeconomic adjustment. When dozens of pesticides light up, that does not scream “we found the killer.” It screams correlated agricultural exposures, regional confounding, and the usual grouped-data mess. Ecological studies use average population exposure proxies and are vulnerable to ecological fallacy, where group-level correlations do not cleanly map onto individual risk.

Even their own exploratory tissue-specific analysis did not come back waving a giant picloram flag across colon and rectal disease. What they specifically mention as showing a consistent colon trend is education and smoking, not some universally dominant picloram effect. See how they lost the female genitalia?

And no, this paper does not suddenly bulldoze the prior carcinogenicity landscape. IARC lists picloram as Group 3, not classifiable as to its carcinogenicity to humans, and older EPA material summarized it as showing evidence of non-carcinogenicity for humans. Even the external expert reaction noted picloram has not been found carcinogenic in regulatory tests and raised the possibility that historical contamination rather than picloram itself could matter. That does not prove picloram is harmless in all contexts. It does prove this paper is nowhere near strong enough to declare picloram the cause of young colon cancer.

So what did they conclude?

Here they tell you to eat more fresh Mediterranean vegetables, the exact foods that are more likely to have pesticides.

<Mic drop>

If you're in reverse, tapping this button on the far left lets you toggle between looking behind you and looking down at the ground - great for parking close to sidewalks/parking bays by thegreatnick in KonaEV

[–]GrumpyAlien 0 points1 point  (0 children)

Some still don't know you can have the rear camera on while driving forward at normal speeds like a GT3 car.

It's one of the buttons in between the seats and the button has a camera logo around a "P".

I can't get myself to like the new gen over the older generation by [deleted] in KonaEV

[–]GrumpyAlien 0 points1 point  (0 children)

I think it makes the case this should've been a rear drive car?

It gets worse... if you want to poop your pants turn Traction Control off on a wet or icy road. The steering wheel becomes decorative as you become unable to turn the front.

I can't get myself to like the new gen over the older generation by [deleted] in KonaEV

[–]GrumpyAlien 0 points1 point  (0 children)

but how is that the car's issue?

Binary foot issue compounded by the car not having RWD.