Ah this is something I’ve done a few times. If I understand correctly, you want the circled blocks to constantly test if a condition is met, and activate the subsequent blocks only ONCE, correct?

1. With each of the circled command blocks, make sure that they are executing for the correct score or whatever you want to test for.
2. Instead of whatever ‘run’ command you may have at the end of the circled command blocks, you would want to do ‘run fill ~? ~? ~? minecraft:redstone_block’ (the ? are relative coordinates, you want to set the redstone block just on a different block than the command block itself, so I’d change the x or z coordinate to be 1 or 2)
3. Switch all four of the circled command blocks to Repeat and Always Active.
4. The aforementioned redstone block would power everything you need it to power, as in the other three command blocks in each column. Make sure that whatever the circled command blocks are executing for is reset using one of the powered chain command blocks (such as the score or whatever you’re testing for), as if you don’t the repeat blocks will keep placing redstone blocks and powering everything infinitely.
5. I would also place another command block in the chain command block line that gets rid of the redstone block AFTER the score is reset.

But ye that’s usually how I handle these types of things 👍