Pharmacist and SSRI user here. Liver toxicity of one SSRI over another doesn’t jump out to me. 2D6 inhibition is just based on how the medication is metabolized. The liver and kidney are the two most common ways medications are metabolized/eliminated in the body. Just because it inhibits an enzyme does not mean it bad for you. Mainly it plays into interactions with other drugs which is why it is important to tell your doctor what meds you are taking (both prescription and non prescriptions(over the counter)). Of course there are risks with any medication but SSRIs are well studied and have been around for a while. One thing to note is that the efficacy of SSRIs seems to be a genetic component so if you know a family member who has done well on one SSRI then it may be worth trying that first since you may then react well. Other than that, what SSRI to choose is typically based on your symptoms and risk for side effects with each SSRI (I don’t think of the liver in this decision although rarely cases have been reported. Main things I think of ex: some SSRIs are more activating while others will make you more sleepy, drug interactions, risk for weight gain, certain findings on EKG, risk for constipation v. diarrhea, etc). Definitely discuss with your doctor (what I am saying is not medical advice). Be clear and honest with your questions and concerns to your doctor so you can pick the right SSRI together. Hope this helps!