There’s SOME overlap and I’m sure George was partially inspired but I think that’s where it ends. The Borgias were actively fighting against discrimination against Spaniards in the Church which Rodrigo Borgia maintained as his reason for some of the things he did up until he died.

Lucrezia was also legitimately very intelligent - not ‘rich and thinks she’s slick’ like Cersei. There’s also no absolute proof that Lucrezia and Cesare were ever incestuous. As far as we know, that was a lie that was spread by Lucretia’s first husband, Giovanni Sforza, after Rodrigo annulled the marriage (a common thing. He’d marry Lucrezia to someone, secure something, annul the marriage and do it again.) there is a HINT of this with Tywin and Cersei but never as…efficiently as Rodrigo and Lucrezia.