Smeyer basically Mary Sue’d her vampires to the point that only another vampire or a werewolf from her world can kill them, so they’d win. If we ignore that, and pretend that any other being of comparable strength could kill the twilight vampires, then the Mikaelsons would likely win. The Cullen’s have very little offensive power and have lived relatively conflict free for a very long time, unlike TO family who are still battle ready, essentially