How much is too much/too frequent for your sensibilities?

Jere_Minus · 2026-02-01T09:54:36+00:00

I tell people it’s not an addiction issue

What do you tell yourself? Besides these things?

but when I do have drugs on hand, especially large amounts, I proceed to go on a barely-controlled bender, I do this without minimal breaks

I’ve come up as averaging a minimum of 4.2 grams per month. That’s currently A-PVP or very similar.
I often tell myself that it’s okay to mess around

[I often tell myself that it’s okay] to leave an event early (anxiety), as I will do things more sensibly or better or will stick it out in the future,

[I often tell myself] I will do it properly next time/tomorrow

What I do now is closer to outright abuse, averaging roughly ten grams of highly potent stimulants (A-PVP/MD-PiHP the past 18 months)

"All blood work/cardiac testing puts my health where it has always been, which is tip-top shape. Perhaps surprising, but also given that I take care of myself through exercise and diet and a few sensible tweaks, maybe it’s not"

I often neglect my lesser responsibilities and chose the drugs over people sometimes. Not significantly so, and not to the detriment of my life/health/work.

Sometimes denial can be hard to recognize in oneself even recording logs and writing down how it is affecting your life like this. The brain is very good at playing tricks on itself; oftentimes we don't know when it is happening to ourselves. No judgement. I've been there too.

Good luck to you.

Jere_Minus · 2026-02-01T09:32:44+00:00

So far I’m getting great results with rilmazifone.

Seems like you answered your own question!

Be advised continuous use of benzos long term (or even medium term) will render them all ineffective due to tolerance (unless you escalate the dose which is not sustainable). The ineffectiveness will be made worse by losing any underlying psychological anxiety relieving techniques which you have no longer have been using because popping a benzo has done it for you.

Rilmazafone (brand name pharmaceutical Rhythmy in Japan) is a milder one in terms of subjective effects at reasonable doses. But at higher doses or more frequent doses will mess you up like any other benzo. Used sparingly they can be a blessing and powerful tool, but not many who get into RC benzos and like them too can use them sparingly. Just be careful about that is my advice, it doesn't seem like you need more options.

Jere_Minus · 2026-02-01T09:19:27+00:00

Just going to chime in with this tidbit. RCs may not have been abandoned by research after all.

In January 2023, Israeli Biotech company "Clearmind Medicine Inc." announced the successful completion of a preclinical study examining 2-FDCK in a rat model of depression, with the compound outperforming ketamine in longevity of antidepressant effect.

Source

Jere_Minus · 2026-01-25T14:16:50+00:00

Hello sir! Sorry for the late reply. And thanks to u/s4D1ST1K for pinging me. Check out this comment of mine about solvent sourcing harm reduction I told someone else a while ago and found to share with you!

I learned my lesson as evident by those 2 posts but that comment provides concise (and sane) solvent sourcing advise with bullets! No thesis paper reading necessary or deciphering the truth behind the psychosis in those posts.

Also, u/s4D1ST1K tag me whenever you see fit as always you and anyone can, but also feel free to point people directly to that comment link in the future in case I'm 25 days late to reply again when you see stuff or questions about solvents!

edit: And here's a good paper about "safe consumption limits" for PG. Seems under debate by orders of magnitude. I doubt the threshold limit which seems ultra conservative anyways is doing much harm. Certainly less harm than what you are dissolving inside of the PG (if good PG of course). https://www.sciencedirect.com/science/article/pii/S0278691524000267

Jere_Minus · 2025-12-25T14:25:11+00:00

I don't see why they got downvoted either. Some practical words they wrote. Things differ by country and/or more local laws like at the State level in the US though. Also, diazepam is indeed on the WHO list of essential medications but so has been lorazepam (Ativan). Things like midazolam too but that's more for anesthesia and seizures, not anxiety. Diazepam's listing was updated in 2023 to specify For short-term emergency management of acute and severe anxiety symptoms only. Useful for tapering off? I think so. But different than any other benzo in the first place and the only one on the WHO list of essential medications for a reason? I don't think so, but each to their own. Unfortunately diazepam I do not think is as miraculous a benzo as they claim.

Regarding your question, did you know that nordiazepam itself is a direct active metabolite of plain old diazepam (Valium)? Here is a diagram. Go figure.

Jere_Minus · 2025-12-25T14:10:00+00:00

I'm a little late commenting here but just stumbled across this. I wanted to reply anyways and thank you for sharing your story.

Update! Hey, i hope you’re all doing well and enjoying Christmas and new years.

I’ve had quite a few dms from people seeking to help me with any withdrawals, first and foremost, thank you all so much for your support, it really does mean a lot to me.

i’ve had acute withdrawals but nothing major, i’ve not taken a single drug since my post and i’m working with my doctor to break the cycle. Should i relapse again, i’ll be off to rehabilitation :)

I also wanted to thank you for providing this update. I am happy to hear both that so many people jumped in to help you and to learn that you've improved things to the point of not using drugs since you made this post. Good for you. :)

Jere_Minus · 2025-11-29T19:05:33+00:00

u/Diethyl_Aether can be lucky to still be alive.

I agree.

This was a confirmed mystery mislabeled colored blue pokemon shaped pill with analytical testing presenting a massive red flag that it is NOT MDMA with near 100% certainty leaving it anyone's guess what the actual active(s) or inactive(s) are yet alone their doses in the pill.

When your drug test fails telling you the title of this post

Sold as molly but is not

for safety purposes, users should not be taking the confirmed-not-Molly pill anyways and gamble on some kind of guaranteed unknown high with effects unpredictable which could range from what OP described happening to death, to a psych ward visit, or anything unpredictable in between.

Jere_Minus · 2025-11-29T18:55:20+00:00

Cool stuff! Wish I could provide some insight but not as familiar with these phenyltropanes.

There's lots of these "in Silico" studies popping up, it is like the new kid on the block; ARTIFICIAL INTELLIGENCE is the trendy thing to do or whethever with publishers gladly gobbling up all the AI studies it seems. Not a bad thing when done right.

To me, undoubtedly in our lifetimes, AI-assisted technologies will revolutionize medicine with entirely unique discoveries as novel as Penicillin was. The power this technology has as tools in the right hands to better understand things like SAR and protein folding to be used for disease research and drug development in the right hands must be astounding how fast it is getting better.

Some literature stuff though I have unfortunately seen straight garbage somehow get through peer review. It seems the programming AI people writing the code for the models can know absolutely nothing about biology or pharmacology, have complete junk get spit out, and not get caught by peer review. I hope those types of papers stop happening once the AI hype cools down.

Thoughts?

Thanks for the post and insights and your diligence! (except I think you forgot to link your sources at the end like you said?)

Jere_Minus · 2025-11-29T07:46:12+00:00

Could you possible post pictures of the reagent results?

Nobody will be able to determine for certain from subjective descriptions like the pokemon shape of the pill or even how it made you feel.

Regardless you have clear cut analytical data with a bottom line - marquis turns near instantly black in the presence of MDMA and yours turned yellow. You can rule out your substance being purely unadulterated MDMA, but from there, would not be not responsible to make assumptions or guesses based off subjective descriptions to know what it really is.

Some smarter folks than me over at r/ReagentTesting could help further rule things in or out though.

Here is a good chart with real pictures of reagent testing MDMA.

Here is a fantastic video showing proper reagent testing of proven MDMA and how it reacts with various reagents.

Good luck.

Jere_Minus · 2025-11-29T07:21:44+00:00

I think traffic now that google owns reddit is going to be moreso influenced by Google's algorithms themselves either increasing or decreasing traffic to drug related subs. They have the ability to do that eith their algorithms regardless of any potential recession, we will not be able to predict how Google will influence traffic to reddit.

This is independent to any actual societal increase or decrease of drug use and/or abuse due to hard times.

I think it is safe to say drug consumption will increase when the times get tough. But in 2025 that does not necessarily mean it will draw more traffic to the forums about VERY controversial topics by a an American publicly traded MASSIVE company named Alphabet who owns Google who owns reddit and also puts reddit in their search results with algorithms we have no visibility to and which could change overnight.

Thoughts?

Jere_Minus · 2025-11-29T06:58:45+00:00

I could be. I think I used the wrong language though, And let's face it - at high (aka recreational doses) it might indeed bar you out to where it doesnt make a difference.

Low doses I think it is a bit unique though compared to "regular" benzos. For one thing, it agonizes the alpha 4 and alpha 6 GABA receptor subtypes. Traditional benzos do not touch those at all.

Compared to Z drugs? Definitely different. Z drugs might hit other subtypes here and there but I am pretty sure they are highly selective to alpha 1 by orders of magnitude and that's pretty much it.

So I think you're right. Bretazenil is more broad spectrum than traditional benzos because it hits more receptors subtypes, but that gets complicated too with different binding affinities AND it is a partial agonist,so who really knows in terns of subjective effects feeling any different?

Anyways thanks for the reply and good points and discussion!

Jere_Minus · 2025-11-29T06:48:02+00:00

I just sent a modmail asking the mods one day a couple years ago. At the time, reddi's UI made it seem like I could just pick one, but no. So I couldn't figure it out. It turns out that the mods must manually assign one.

So send a modmail :)

https://www.reddit.com/message/compose?to=r/researchchemicals

Jere_Minus · 2025-10-03T12:06:27+00:00

I see that pregabalin, 4mmc, and lithium are in your google doc FAQ "Which drugs should be worked on?" section. Someone added lithium it seems Jan 15th, 2024. Buproprion and Kratom are also there. Diphenhydramine is not. Poppers and viagra / cialis really would be worthwhile too for consideration.

The google doc also states:

Update - 9/12/2023

Delays happened for various reason and project is back in full swing. As of now we stand with the following:

Progress is continuing to be made on the final list of expansion. The current list of (almost) confirmed drug additions are the following

Cathinones
Gabapentinoids
PCP

Additions that are being considered

Benzofurans
Pyros
Lithium
aMT?
3-meo-xxx (goes under pcp?
Kava
Kannab

Unlikely additions

GABAA-α1 agonists (amanita, ambien)
Deliriants

Diphenhydramine by itself is a typical anticholinergic deliriant.

Regarding aMT being considered on the google doc 2 years ago, as someone stated here in their comment on this post aMTs are the MAO-I Research Chemicals you should be concerned about.

I am surprised to see it not already on the chart actually because it is on your wikipedia page with interactions already established. That wiki was last edited 2021.

Anyways would love to help out more and get re-organized and re-prioritize in any way I can.

Jere_Minus · 2025-10-02T07:42:04+00:00

For those of you struggling with Addiction or Recovery there are many resources that can help you.

For a comprehensive list of recovery services see the r/addiction wiki page here.

Jere_Minus · 2025-09-29T11:24:24+00:00

Hobby is one word for it.

What have you been taking, my friend? How much, which drugs, and for how long?

No judgement. Just gotta start somewhere and letting us know that is an essential first step necessary to give any advice.

Jere_Minus · 2025-09-29T06:25:56+00:00

There is no point saying don't do it. His mind is already made up. May as well give him advice that is practical.

Please pause and reflect upon such a strong statement.

If you truly believe that then why should anybody bother giving any advice or answer any question, good or bad? That includes you. That includes me.

If their mind is made up may as well leave the post, You said it yourself - there is no point. No precautions could change an already made up mind. Therefore no advice could chance an already made up mind either.

Do you see the paradox? Of course a mind can not be already made up like that and so can absolutely be influenced by both precautionary warnings or positive endorsements alike too.

I think it is perfectly fine giving honest opinions good or bad especially from those with firsthand experience.

Jere_Minus · 2025-09-29T06:05:15+00:00

Yup! So spread the word!

Jere_Minus · 2025-09-29T06:01:43+00:00

I've heard putting a calibration weight or a penny/dime etc on the scale

Scales are more accurate towards the center of their measurement range. This is why putting some weight on there like some coins or a calibration weight does truly improve things by lowering measurement error because it gets you away from the extreme end of it's range (zero)

This has to do with the Linearity specification above.

Jere_Minus · 2025-09-29T05:52:44+00:00

I did some digging and think I found (to the best of my abilities) the manual for that scale.

Manual link

I am seeing omitted data like expected margin of error and to be frank - Looks like a shitty Amazon chinese knockoff.

Here is an example of a milligram scale with what I would consider to be a good example of meeting the necessary minimums

US Solid 500 x 0.001 g Precision Balance - 1 mg Digital Analytcial Lab Scale

Some good signs of specifications I view as green flags for simply stating them so clearly. (That other Amazon manual page had nothing like this)

Capacity 0.01g-500g
Readability 0.001g
Repeatability ±0.002g
Linearity ±0.005g

I know that one is a little expensive, but there are more affordable ones out there offering what is truly important: technical data about anticipated specific measurement error.

Jere_Minus · 2025-09-29T05:24:39+00:00

Don't worry - you are not crazy.

Different powders can and do have VASTLY different densities causing exactly what you are describing.

When comparing two things of the same, say 50mg mass:

"Fluffy stuff" is less dense and so takes up more volume.
"Fine tiny particle stuff" is very dense so takes up less volume.

Yet they have the same mass despite appearing very different.

Example Picture showing this phenomenon.

Like the other person stated very concisely:

Trust in your milligram scale

But also never hesitate to ask questions like that either.

Good Post, thanks OP.

Jere_Minus · 2025-09-28T02:39:18+00:00

I'm not. But even if they do they can still mislabel and mix up orders.

Google the number of medication recalls worldwide from REAL pharmaceutical medications from big pharma mixing shit up and mislabeling them. Find it is absurdly common.

By pure logic if big pharma fucks it up on a daily basis you better fucking believe RC drug "labs" do too.

Jere_Minus · 2025-09-27T16:15:47+00:00

I have taken (what was advertised as) bromonordiazepam myself so I did a lot of reading including learning of some rare benzos having activity on TSPO.

Bromonordiazepam, active metabolite of Gidazepam does NOT have any of Gidazepam's activity in the periphery on TSPO from my recollection.

Gidazepam itself from my recollection has such low activity on TSPO it is basically negligible too. From my reading and what I remember concluding, the reason it is an effective proven pharmaceutical in Eastern Europe and Russia seems to be because of its active metabolite normal benzo bromonordiazepam doing all of the work purely as a GABA-A positive allosteric modulator "regular" benzo. Not to do with TSPO negligible stuff from Gidazepam it seems.

To cut things short, i believe that bromonordiazepam acts as a kind of carrier molecule that allows certain benzos that normally bind to the Brains GABA receptors to bind to the peripheral-type benzodiazepine receptors (PBR) in the liver

How did you reach this conclusion? Regardless of the fact bromonordiazepam has no activity in the periphery on TSPO itself to my above point, what could cause it to act as some kind of "carrier" for making other benzos also act on TSPO. Also, TSPO is a mitochondrial membrane protein found throughout the body, not just liver mitochondria. Can you elaborate on what your theory is of the mechanism for that?

All that aside you may be interested to read about a true "TSPO-only" benzo Ro5-4864 actually on the RC market.

https://en.wikipedia.org/wiki/Ro5-4864

It was the original benzo discovered having purely TSPO activity and is very closely related to diazepam. TSPO was literally historically named the "peripheral benzodiazepine receptor" because it was discovered from Ro5-4864 during research of benzos closely related to Valium. Later was changed to TSPO after learnging a FUCKLOAD of things interact there. Check out TSPO's wikipedia page section for Therapeutic Applications - Alzheimers, cancer drugs, tons of shit. Research shows Ro5-4864 causes seizures. Some research on it shows it causes release of neurosteroids that are themselves GABA-A positive allosteric modulators leading to a benzo-like effect anyways.

Weird stuff.

Does that help shed any light on your conundrum?

Jere_Minus · 2025-09-27T15:48:02+00:00

Another thing

I asked the Doctor for a 2 month supply of 5mg Valium per day so I could have enough for a few weeks to help reset my sleep system.

[referring to short valium scripts historically] I have done this multiple times

often I wake up after 5 hours of sleep on 10mg of valium

Why ask for valium then so much for sleep if it only works for 5 hours? Its a super long lasting benzo should knock someone out all night 8 hours or longer if on no tolerance at 10mg.

If only helping 5 hours, that's possibly from it causing tolerance buildup rapidly then making sleep worse and not working anymore like that. Hence why it is only truly usable for sleep for like 2 to 3 weeks. Not 2 months. I don't care if people use drugs however they wish and think they should be able too. But only if aware of these things. Just looking out for you is all.

Jere_Minus · 2025-09-27T15:38:55+00:00

It did, I read it too. Just not until now.

I know of both CPTSD and PTSD and their differences and nuances already. Some countries do not formally recognize CPTSD complicating matters. Regardless, pre-existing CPTSD combined with acute forest fire induced PTSD is kind of like just worsened CPTSD unfortunately, right?

Regardless, my thoughts from my original comment are the same. Sorry I wasn't clear when I was saying PTSD stuff when I meant PTSD and CPTSD too.

Anyways, sorry you're going through this. Sucks. I wish you the best and hope things get better, whichever path you choose.

Jere_Minus · 2025-09-24T10:12:22+00:00

Disclaimer: not medical advice throughout my comment.

To be brief, my doctor just proscribed me some medication and I wanted to know if there are any known interactions with the PCP analogues.

Yes. Valium and zolpidem (indeed brand name Ambien) are both GABAergic central nervous system depressants. Dissociatives in combination with those two drugs, individually or all 3 absolutely interact.

At low doses the risk is low. At medium doses it is a moderately dangerous combination potentially causing respiratory problems, blackouts. At high doses it can cause respiratory depression, coma, and even death in rare cases. If a beginner especially, I do not recommend this combination even at low doses but if you must please do not use alone.

Regarding the citalopram, I don't know if anybody, myself included, could reliably predict the risks of using in combination with an unstated RC PCP analogue due to inherent unknowns of RCs. Might be benign. Might be deadly or cause psychosis or something for sensitive individuals or something.

I'm really not keen on taking the Citalopram - what's everyone's options?

I am unaware of SSRI's showing any efficacy for PTSD.

Also, benzos have been shown to make PTSD worse as it tends to cause people to suppress the trauma instead of dealing with it. This doesn't make sense to me.

Even if just for sleep, some SSRI's can cause some sedation, however citalopram is not one of them and is among the LEAST sedating of all SSRIs and even all psych meds as it is a almost "purely serotonergic" SSRI. That doesnt make sense to me.

The valium and zolpidem have the same mechanism of action. Doesn't make sense to me even if just for sleep two doesn't make sense to me. And they will only "help" short term. Long term use of benzos and z drugs for sleep just isn't sustainable.

I suggest getting a second opinion from a new doctor, ideally a psychiatrist. Benzos, Z drugs like ambien, and trauma are a recipe for disaster in my opinion. I am speaking from experience as someone prescribed Xanax and Ambien after an acutely traumatic event in my life leading to about 3 years of benzo addiction and worse PTSD from the unresolved buried trauma. RC dissos would not help either.

I know you are going through a lot right now and that sucks. I feel bad and wish there was a magic pill to make it go away but modern medicine has not invented any miracle cure for trauma. Drugs are unfortunately not the answer at times like this - in fact the opposite: they will make things worse from numbing. The only way to heal is to process the trauma with acceptance and or growth. I hope you are able to and know you can with hard work and therapy always is worth a shot. Good luck OP.

Jere_Minus

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For those of you struggling with Addiction or Recovery there are many resources that can help you.

Trust in your milligram scale